Evidence map›Paper›PMID 31167784›Full record

ArticleThe Journal of biological chemistry2019

Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells.

Joshua K Stone, Jung-Hyun Kim, Lana Vukadin, Alexander Richard, Hannah K Giannini, Ssang-Taek Steve Lim, Ming Tan, Eun-Young Erin Ahn

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
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  7. Downregulation ofBiochemistry and biophysics reports · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Hypoxia-driven ncRNAs in breast cancer.Frontiers in oncology · 2023
    Review
  12. Article
  13. Noncoding RNAs as sensors of tumor microenvironmental stress.Journal of experimental & clinical cancer research : CR · 2022
    Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joshua K StoneMitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Jung-Hyun KimMitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.ORCID 0000-0001-7176-409X
Lana VukadinMitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Alexander RichardMitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Hannah K GianniniMitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Ssang-Taek Steve LimDepartment of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688.ORCID 0000-0003-0323-8607
Ming TanMitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Eun-Young Erin AhnMitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604 eahn@health.southalabama.edu.ORCID 0000-0001-8795-7734
USA Mitchell Cancer Institute · USUniversity of South Alabama · US

Funding

SON-mediated gene expression and leukemiaR01CA190688 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI AHN, ERIN EUN-YOUNG · 2016 to 2021
$1.7M
Role of FAK in vascular inflammationR01HL136432 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LIM, STEVE · 2017 to 2020
$1.6M
Glucose metabolism and ErbB2-mediated cancer progressionR01CA149646 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI TAN, MING · 2011 to 2016
$1.4M
SON and the MALAT1 locus in chromatin interaction and metastasis gene regulationR21CA185818 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI AHN, ERIN EUN-YOUNG · 2015 to 2016
$362k
NCI NIH HHS R01 CA149646NCI NIH HHS R01 CA190688NCI NIH HHS R21 CA185818NHLBI NIH HHS R01 HL136432
6 · The paper itself

Abstract

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA overexpressed in various cancers that promotes cell growth and metastasis. Although hypoxia has been shown to up-regulate MALAT1, only hypoxia-inducible factors (HIFs) have been implicated in activation of the

Indexed as

Cell HypoxiaBreast NeoplasmsCell Line, TumorChromatinEnhancer Elements, GeneticHumansPromoter Regions, GeneticProtein BindingRNA, Long NoncodingUp-RegulationChromatinMALAT1 long non-coding RNA, humanRNA, Long Noncodingbreast cancerchromatin structurehistone modificationhypoxialong noncoding RNA (long ncRNA, lncRNA)MALAT1

Identifiers

PMID31167784
PMCPMC6643033
OpenAlexW2948789868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.