GuidelineAnnals of the rheumatic diseases2020
2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout.
Guideline in Annals of the rheumatic diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 7 of them syntheses that pooled it.
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Who cites it
179 citing papers in PubMed, 7 syntheses or guidelines pooled it, 413 citations in OpenAlex.
- Efficacy and safety of urate-lowering therapies in asymptomatic hyperuricaemia: a systematic review and network meta-analysis of key clinical outcomes.Annals of medicine · 2025Pooled it
- Impact of gout on cardiovascular disease mortality: a meta-analysis.Zeitschrift fur Rheumatologie · 2024Pooled it
- 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice.Annals of the rheumatic diseases · 2024Guideline
- Meta-analysis and systematic review of gout prevalence in the heart/lung transplantation population.Frontiers in transplantation · 2024Pooled it
- Pooled it
- Assessment and diagnosis of the acute hot joint: a systematic review and meta-analysis.Rheumatology (Oxford, England) · 2023Pooled it
- Reporting quality of clinical practice guidelines regarding gout and hyperuricemia according to the RIGHT checklist: systematic review.Systematic reviews · 2021Pooled it
- Rapid and regular dose escalation in urate lowering therapy: a pragmatic clinical trial.Clinical rheumatology · 2026Trial
- Health outcomes associated with patient-perceived gout aetiology: a cross-sectional analysis of the GAPP Study baseline data.Clinical rheumatology · 2026Trial
- Efficacy and safety of epaminurad, a potent hURAT1 inhibitor, in patients with gout: a randomized, placebo-controlled, dose-finding study.Arthritis research & therapy · 2025Trial
- Deciphering the interplay between serum urate and bone mineral density: insights from observational and genetic perspectives.Journal of the International Society of Sports Nutrition · 2026Article
- Expert consensus on urate‑lowering therapy for high‑risk hyperuricemia (2026 edition).Chinese medical journal · 2026Article
- Gout: a practical approach to diagnosis and management in low- and middle-income countries and resource-limited settings.Clinical rheumatology · 2026Review
- Explainable Clinical Decision Support for Metabolic Index Prediction in Gout Patients Using GA-Optimized Ensemble Learning Models.Diagnostics (Basel, Switzerland) · 2026Article
- Integrative multi-omics analysis unravels the metabolic landscape and reveals serum biomarkers for early diagnosis of hyperuricemia.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Axial gout diagnosed by dual-energy CT in a young normouricaemic man with recurrent nephrolithiasis: a case-based review.Rheumatology international · 2026Review
- Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout.Neuroscience bulletin · 2026Article
- A Lipid- and Inflammation-Related Metabolite Risk Score Predicts Incident Gout Among Individuals With Hyperuricemia: A Prospective Cohort Study.Clinical rheumatology · 2026Article
- [Gout of the manubriosternal joints: A case report].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Epidemiological trends and burden of gout in China and the European Union: a GBD 2023 and Mendelian randomization study.Clinical rheumatology · 2026Article
119 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 16 institutions in 11 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed. New data on imaging and clinical diagnosis have become available since the first EULAR recommendations for the diagnosis of gout in 2006. This prompted a systematic review and update of the 2006 recommendations. A systematic review of the literature concerning all aspects of gout diagnosis was performed. Recommendations were formulated using a Delphi consensus approach. Eight key recommendations were generated. A search for crystals in synovial fluid or tophus aspirates is recommended in every person with suspected gout, because demonstration of monosodium urate (MSU) crystals allows a definite diagnosis of gout. There was consensus that a number of suggestive clinical features support a clinical diagnosis of gout. These are monoarticular involvement of a foot or ankle joint (especially the first metatarsophalangeal joint); previous episodes of similar acute arthritis; rapid onset of severe pain and swelling; erythema; male gender and associated cardiovascular diseases and hyperuricaemia. When crystal identification is not possible, it is recommended that any atypical presentation should be investigated by imaging, in particular with ultrasound to seek features suggestive of MSU crystal deposition (double contour sign and tophi). There was consensus that a diagnosis of gout should not be based on the presence of hyperuricaemia alone. There was also a strong recommendation that all people with gout should be systematically assessed for presence of associated comorbidities and risk factors for cardiovascular disease, as well as for risk factors for chronic hyperuricaemia. Eight updated, evidence-based, expert consensus recommendations for the diagnosis of gout are proposed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.