Evidence map›Paper›PMID 31167476›Full record

ReviewInternational journal of molecular sciences2019

Antimicrobial Polymers: The Potential Replacement of Existing Antibiotics?

Nor Fadhilah Kamaruzzaman, Li Peng Tan, Ruhil Hayati Hamdan, Siew Shean Choong, Weng Kin Wong, Amanda Jane Gibson, Alexandru Chivu, Maria de Fatima Pina

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it, 235 citations in OpenAlex.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nor Fadhilah KamaruzzamanFaculty of Veterinary Medicine, Locked bag 36, Universiti Malaysia Kelantan, Pengkalan Chepa 16100, Kelantan, Malaysia. norfadhilah@umk.edu.my.ORCID 0000-0002-3092-1201
Li Peng TanFaculty of Veterinary Medicine, Locked bag 36, Universiti Malaysia Kelantan, Pengkalan Chepa 16100, Kelantan, Malaysia. li.peng@umk.edu.my.ORCID 0000-0003-1668-3224
Ruhil Hayati HamdanFaculty of Veterinary Medicine, Locked bag 36, Universiti Malaysia Kelantan, Pengkalan Chepa 16100, Kelantan, Malaysia. ruhil@umk.ed.my.
Siew Shean ChoongFaculty of Veterinary Medicine, Locked bag 36, Universiti Malaysia Kelantan, Pengkalan Chepa 16100, Kelantan, Malaysia. shean.cs@umk.edu.my.
Weng Kin WongSchool of Health Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia. wengkinwong@usm.my.ORCID 0000-0003-2189-638X
Amanda Jane GibsonRoyal Veterinary College, Pathobiology and Population Sciences, Hawkshead Lane, North Mymms, Hatfield AL9 7TA, UK. ajgibson@rvc.ac.uk.
Alexandru ChivuUCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London NW3 2PF, UK. a.chivu.14@ucl.ac.uk.
Maria de Fatima PinaMedicines and Healthcare Regulatory Products Agency, 10 South Colonnade, Canary Wharf, London E14 4PU, UK. mfatimagpina@gmail.com.
Universiti Malaysia Kelantan · MYLondon Centre for Nanotechnology · GBRoyal Veterinary College · GBUniversiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is now considered a major global challenge; compromising medical advancements and our ability to treat infectious disease. Increased antimicrobial resistance has resulted in increased morbidity and mortality due to infectious diseases worldwide. The lack of discovery of novel compounds from natural products or new classes of antimicrobials, encouraged us to recycle discontinued antimicrobials that were previously removed from routine use due to their toxicity, e.g., colistin. Since the discovery of new classes of compounds is extremely expensive and has very little success, one strategy to overcome this issue could be the application of synthetic compounds that possess antimicrobial activities. Polymers with innate antimicrobial properties or that have the ability to be conjugated with other antimicrobial compounds create the possibility for replacement of antimicrobials either for the direct application as medicine or implanted on medical devices to control infection. Here, we provide the latest update on research related to antimicrobial polymers in the context of ESKAPE (

Indexed as

AnimalsAnti-Bacterial AgentsAnti-Infective AgentsBacteriaBacterial InfectionsChemical PhenomenaDrug DevelopmentDrug Resistance, MicrobialHalogensHumansMolecular StructurePolymersPopulation SurveillanceStructure-Activity RelationshipSurface-Active AgentsAnti-Bacterial AgentsAnti-Infective AgentsHalogensPolymersSurface-Active Agentsantimicrobial polymersantimicrobial resistanceESKAPE pathogens

Identifiers

PMID31167476
PMCPMC6600223
OpenAlexW2948379485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.