Evidence map›Paper›PMID 31167363›Full record

ArticleMolecules (Basel, Switzerland)2019

Design, Synthesis and Biological Evaluation of a New Series of 1-Aryl-3-{4-[(pyridin-2-ylmethyl)thio]phenyl}urea Derivatives as Antiproliferative Agents.

Chuanming Zhang, Xiaoyu Tan, Jian Feng, Ning Ding, Yongpeng Li, Zhe Jin, Qingguo Meng, Xiaoping Liu, Chun Hu

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Synthesis of NovelMolecules (Basel, Switzerland) · 2022
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chuanming ZhangKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. chuanming_zhang@yeah.net.
Xiaoyu TanKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. tanxiaoyuaikaoyan@163.com.
Jian FengKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. mr.fengjian@foxmail.com.
Ning DingKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. dingning2216@163.com.
Yongpeng LiKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. yongpengli1993@163.com.
Zhe JinKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. jinzheln@163.com.
Qingguo MengDepartment of Pharmacy, Yantai University, Yantai 264005, China. qinggmeng@163.com.
Xiaoping LiuKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. lxp19730107@163.com.
Chun HuKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. chunhu@syphu.edu.cn.ORCID 0000-0003-2919-2870

Funding

National Natural Science Foundation of China 21342006
6 · The paper itself

Abstract

To discover new antiproliferative agents with high efficacy and selectivity, a new series of 1-aryl-3-{4-[(pyridin-2-ylmethyl)thio]phenyl}urea derivatives (

Indexed as

Drug DesignAntineoplastic AgentsApoptosisCell CycleCell Line, TumorChemistry Techniques, SyntheticDrug Screening Assays, AntitumorHumansHydrogen BondingMolecular StructurePhenylurea CompoundsSpectrum AnalysisStructure-Activity RelationshipAntineoplastic AgentsN-phenylureaPhenylurea Compoundsantiproliferative activityantiproliferative agentapoptosissynthesisurea

Identifiers

PMID31167363
PMCPMC6600452

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.