Evidence map›Paper›PMID 31167346›Full record

ReviewNutrients2019

Vegetable-Based Diets for Chronic Kidney Disease? It Is Time to Reconsider.

Aleix Cases, Secundino Cigarrán-Guldrís, Sebastián Mas, Emilio Gonzalez-Parra

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Aleix CasesMedicine Department, Universitat de Barcelona, Institut d'Investigacions Biomèqiques August Pi i Sunyer, 08036 Barcelona, Spain. acases@clinic.cat.ORCID 0000-0002-6962-8184
Secundino Cigarrán-GuldrísServicio de Nefrología, Hospital da Costa, 27880 Burela, Spain. Secundino.Cigarran.Guldris@sergas.es.
Sebastián MasServicio de Nefrología, Fundación Jiménez Díaz, 28040 Madrid, Spain. smas@fjd.es.ORCID 0000-0001-6604-3327
Emilio Gonzalez-ParraServicio de Nefrología, Fundación Jiménez Díaz, 28040 Madrid, Spain. EGParra@senefro.org.
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESHospital Universitario Fundación Jiménez Díaz · ESUniversitat de Barcelona · ES

Funding

Ministerio de Economía, Industria y Competitividad, Gobierno de España PI16/01298
6 · The paper itself

Abstract

Traditional dietary recommendations to renal patients limited the intake of fruits and vegetables because of their high potassium content. However, this paradigm is rapidly changing due to the multiple benefits derived from a fundamentally vegetarian diet such as, improvement in gut dysbiosis, reducing the number of pathobionts and protein-fermenting species leading to a decreased production of the most harmful uremic toxins, while the high fiber content of these diets enhances intestinal motility and short-chain fatty acid production. Metabolic acidosis in chronic kidney disease (CKD) is aggravated by the high consumption of meat and refined cereals, increasing the dietary acid load, while the intake of fruit and vegetables is able to neutralize the acidosis and its deleterious consequences. Phosphorus absorption and bioavailability is also lower in a vegetarian diet, reducing hyperphosphatemia, a known cause of cardiovascular mortality in CKD. The richness of multiple plants in magnesium and vitamin K avoids their deficiency, which is common in these patients. These beneficial effects, together with the reduction of inflammation and oxidative stress observed with these diets, may explain the reduction in renal patients' complications and mortality, and may slow CKD progression. Finally, although hyperkalemia is the main concern of these diets, the use of adequate cooking techniques can minimize the amount absorbed.

Indexed as

DietGastrointestinal MicrobiomeRenal Insufficiency, ChronicVegetablesHumansCKDdietary acid loadfibergut microbiotahyperkalemiaphosphorusuremic toxinsvegetable-based diet

Identifiers

PMID31167346
PMCPMC6627351
OpenAlexW2948168326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.