ArticleAmerican journal of nephrology2019
Histological Evidence of Diabetic Kidney Disease Precede Clinical Diagnosis.
Article in American journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 36 citations in OpenAlex.
- Plasma apolipoprotein M level and estimated glomerular filtration rate in type 2 diabetes patients with and without albuminuria.Scientific reports · 2026Article
- Development and validation of an early risk prediction model based on inflammatory and metabolically derived markers for early diagnosis of diabetic kidney disease.Scientific reports · 2026Article
- HistoGWAS: an AI-enabled framework for automated genetic analysis of tissue phenotypes in histology cohorts.Genome biology · 2026Article
- Explainable Artificial Intelligence for Early Diabetic Kidney Disease Risk Profiling in Type 2 Diabetes: Translational Readiness and Clinical Boundaries.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- The diagnostic value and mechanism of miR-127-3p in type 2 diabetes and complications of diabetic nephropathy.Hereditas · 2025Article
- Aucubin ameliorates diabetic kidney disease by restoring hGENCs autophagy through promoting phosphorylation of ATG4B protein.Renal failure · 2025Article
- Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice.Inflammation · 2025Article
- MRI-based quantification of whole-organ renal metabolic rate of oxygen during free-breathing.Magnetic resonance in medicine · 2025Article
- The Role of miR-802 in Diabetic Kidney Disease: Diagnostic and Therapeutic Insights.International journal of molecular sciences · 2025Review
- Clinical significance of hyperuricaemia in biopsy-proven diabetic kidney disease ━ a single-centre retrospective study.Frontiers in endocrinology · 2025Article
- Article
- Transient albuminuria in the setting of short-term severe hyperglycemia in type 1 diabetes.Journal of diabetes and its complications · 2024Article
- Targeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease.Drug delivery · 2023Article
- Renal elasticity and perfusion changes on ultrasonography in an early-stage diabetic rat model.Quantitative imaging in medicine and surgery · 2023Article
- Histological findings of diabetic kidneys transplanted in non-diabetic recipients: a case series.International urology and nephrology · 2023Article
- Presence of Non-Diabetic Kidney Diseases in Biopsy Specimens of Diabetic Patients' Single Center Experience.International journal of molecular sciences · 2023Article
- Heterogeneity in Kidney Histology and Its Clinical Indicators in Type 2 Diabetes Mellitus: A Retrospective Study.Journal of clinical medicine · 2023Article
- Plasma galectin-3 concentration and estimated glomerular filtration rate in patients with type 2 diabetes with and without albuminuria.Scientific reports · 2022Article
- Clinical and Histological Predictors of Renal Survival in Patients with Biopsy-Proven Diabetic Nephropathy.Kidney diseases (Basel, Switzerland) · 2022Article
- Recovering histological sections for ultrastructural diagnosis of glomerular diseases through the pop-off technique.Journal of nephrology · 2021Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIn the absence of a histological diagnosis, persistent albuminuria is globally accepted as the main diagnostic criteria for diabetic kidney disease (DKD).
methodsIn the present retrospective study, we evaluated data from an Italian cohort of 42 deceased diabetic donors (mainly with type 2 diabetes). Using the kidney biopsies obtained at the time of donation to evaluate single or double allocation based on Karpinski score, we determined the prevalence of histological lesions attributable to diabetes.
resultsAll 42 donors presented with proteinuria in the normal range and an estimated glomerular filtration rate (eGFR) (chronic kidney disease [CKD]-EPI) >60 mL/min/1.73 m2. A kidney biopsy was available for 36 patients; of these, one was not interpretable and 32 showed histopathological lesions consistent with DKD and encompassing all histological classes. Thus, we found a relatively high proportion of histologically proven DKD that had been clinically undiagnosed, as none of the patient had significant proteinuria and eGFR <60 mL/min/1.73 m2.
conclusionsThe data we present here support the need to implement routine kidney biopsies in normoalbuminuric diabetic subjects in the early stages of CKD. Such strategy may help to improve risk stratification in diabetic patients and guide therapeutic decisions during the early stages of the disease.
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