Evidence map›Paper›PMID 31167118›Full record

ArticleCell metabolism2019

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.

Curtis C Hughey, Peter A Crawford

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Genes · 2024
    Article
  5. Review
  6. TheFoods (Basel, Switzerland) · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Curtis C HugheyDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: chughey@umn.edu.
Peter A CrawfordDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: crawforp@umn.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

Indexed as

Citric Acid CyclePyruvate CarboxylaseAntioxidantsGluconeogenesisLiverOxidation-ReductionPyruvatesAntioxidantsPyruvate CarboxylasePyruvates

Identifiers

PMID31167118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.