ArticleSchizophrenia bulletin2020
Neighborhood Characteristics at Birth and Positive and Negative Psychotic Symptoms in Adolescence: Findings From the ALSPAC Birth Cohort.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2022Pooled it
- Environmental Exposures and Computational Mechanisms in Psychosis Risk: Insights from a Multi-Site Cohort.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review.JCPP advances · 2026Article
- The longitudinal association between adverse childhood experiences and persistence of psychotic-like experiences in young people: evidence from the ALSPAC birth cohort.Psychological medicine · 2026Article
- Neighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons.Brain and environment · 2026Article
- Environmental deprivation is associated with reward processing impairments and negative symptoms in schizophrenia.Schizophrenia research · 2025Article
- Association Between Urban Upbringing and Cortical Gyrification in Persons with Schizophrenia.Indian journal of psychological medicine · 2025Article
- Family Socioeconomic Position and Eating Disorder Symptoms Across Adolescence.JAMA network open · 2025Article
- Deprivation and well-being in squalid living: a propensity score matched cross-sectional study of the English Housing Survey.BMC public health · 2025Article
- Debate: Urban-rural environments - which is better for mental health? Moving beyond urban-rural dichotomies in psychosis risk for young people.Child and adolescent mental health · 2025Article
- Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis.Schizophrenia research · 2025Article
- Longitudinal association between neighborhood-level social capital and incidence of major psychiatric disorders in a cohort of 1.4 million people in Sweden.Nature. Mental health · 2025Article
- Assessment of common mental disorders in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort at age 24 years using the Clinical Interview Schedule-Revised (CIS-R).Wellcome open research · 2025Article
- Childhood Adversity and Incident Psychotic Experiences in Early Adulthood: Cognitive and Psychopathological Mediators.Schizophrenia bulletin · 2024Article
- Air and Noise Pollution Exposure in Early Life and Mental Health From Adolescence to Young Adulthood.JAMA network open · 2024Article
- Psychosis superspectrum I: Nosology, etiology, and lifespan development.Molecular psychiatry · 2024Review
- Polygenic risk for schizophrenia, social dispositions, and pace of epigenetic aging: Results from the Young Finns Study.Aging cell · 2024Article
- The social determinants of mental health and disorder: evidence, prevention and recommendations.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Association between urban upbringing and functional brain connectivity in schizophrenia.Indian journal of psychiatry · 2024Article
- Urbanicity and psychotic disorders: Facts and hypotheses.Dialogues in clinical neuroscience · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundUrban birth is associated with risk of non-affective psychoses, but the association with subclinical positive and negative symptoms is less clear, despite emerging evidence. Further the extent to which these findings are confounded by polygenic risk scores (PRS) for schizophrenia is also unknown.
methodsUsing data from the Avon Longitudinal Study of Parents and Children, linked to census geographical indicators, we examined whether various indices of urbanicity at birth were associated with negative and positive psychotic symptoms at age 16 and 18 years, respectively. We used logistic regression models, controlling for child's ethnicity, maternal age, education, marital status, social class, depressive symptoms, other neighborhood exposures, and, in a subsample of children of white ethnicity (N = 10 283), PRS for schizophrenia.
resultsAmongst 11 879 adolescents, those born in the most densely populated tertile had greater odds of reporting positive psychotic experiences, after multivariable adjustment (odds ratio [OR]: 1.57, 95% confidence intervals (CIs): 1.14-2.17). Adolescents born in the most socially fragmented neighborhoods had greater odds of negative symptoms, after multivariable adjustment (OR: 1.43, 95% CI: 1.06-1.85). Although we found that greater schizophrenia PRS were associated with an increased risk of being born in more deprived and fragmented (bot not more densely populated areas), these associations were not confounded by PRS.
interpretationBirth into more densely populated and socially fragmented environments increased risk of positive and negative psychotic phenomena in adolescence, respectively, suggesting that different forms of neighborhood social adversity may impinge on different psychopathophysiologies associated with the clinical expression of psychosis.
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