Evidence map›Paper›PMID 31166783›Full record

SynthesisAIDS patient care and STDs2019

Recent Interventions to Improve Retention in HIV Care and Adherence to Antiretroviral Treatment Among Adolescents and Youth: A Systematic Review.

Marisa Casale, Anna Carlqvist, Lucie Cluver

2 registry-linked trialsOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in AIDS patient care and STDs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 111 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 11 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05010317 nacompletednot on this mapstarted 2022, after this paper: background citation

Acceptability, Feasibility and Effectiveness of a Mindfulness Based Intervention to Promote Adherence to Antiretroviral Therapy Among Adolescents in Kampala.

TypeinterventionalSponsorInfectious Diseases Research Collaboration, UgandaRan2022 to 2023Enrolled122ConditionsMedication Adherence, Adjustment Reaction With Anxiety and Depression, Mental Health IssueArmsMindfulness and acceptance based therapy, Standard of care
NCT05278559 unknown statusnot on this mapstarted 2022, after this paper: background citation

Can Undetectable (Viral Load) = Untransmissible (Virus) Change the Life Course of Adolescents Living the HIV in Africa

TypeobservationalSponsorCentre for Sexual Health and HIV/AIDS Research ZimbabweRan2022 to 2024Enrolled300ConditionsHIV/AIDS
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 11 syntheses or guidelines pooled it, 189 citations in OpenAlex.

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51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Marisa Casale1 Department of Social Policy and Intervention, University of Oxford, Oxford, United Kingdom.
Anna Carlqvist1 Department of Social Policy and Intervention, University of Oxford, Oxford, United Kingdom.
Lucie Cluver1 Department of Social Policy and Intervention, University of Oxford, Oxford, United Kingdom.
Oxford Policy Management · GBUniversity of Oxford · GB

Funding

HSRD VA CDP 13-003Medical Research Council MR/R022372/1
6 · The paper itself

Abstract

Adolescents represent a growing proportion of people living with HIV worldwide and the highest risk population group for treatment attrition and AIDS-related mortality. There is an urgent need to design, implement, and test interventions that keep young people in HIV treatment and care. However, previous systematic reviews show scarce and inconclusive evidence of effective interventions for this age group. Recent years have seen an increase in focus on adolescent health and a rapidly changing programmatic environment. This systematic review article provides an evidence update by synthesizing empirical evaluations of interventions designed to improve antiretroviral therapy adherence and retention among adolescents (10-19) and youth (15-24) living with HIV, published between January 2016 and June 2018. A search of 11 health and humanities databases generated 2425 citations and 10 relevant studies, the large majority conducted in sub-Saharan Africa. These include six clinic-level interventions, one individual-level m-Health trial, and three community- or household-level interventions. Implications of their findings for future programming and research with young adults are discussed, in relation to previous reviews and the broader empirical evidence in this area. Findings highlight the need to further develop and test multi-faceted interventions that go beyond health facilities, to address broader social barriers to adherence and retention. In particular, further intervention studies with adolescents (10-19) should be a priority, if we are to retain these young people in treatment and care and aspire to achieve the United Nation's Sustainable Development Goals and 90-90-90 targets.

Indexed as

Medication AdherenceAdolescentAfrica South of the SaharaAnti-Retroviral AgentsDelivery of Health CareFemaleHIV InfectionsHumansMaleRisk FactorsTreatment OutcomeYoung AdultAnti-Retroviral AgentsadolescentsHIV treatment adherenceretention in HIV caresystematic reviewyouth

Identifiers

PMID31166783
PMCPMC6588099
OpenAlexW2949022817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.