Evidence map›Paper›PMID 31166711›Full record

ArticleAmerican journal of physiology. Cell physiology2019

Pressure-dependent modulation of inward-rectifying K

Rachel A Fischer, Abigail L Roux, Lauren K Wareham, Rebecca M Sappington

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Biopolymer Membranes for Osmotic Power Generation in Bionic Applications.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  3. The role of RGC degeneration in the pathogenesis of glaucoma.International journal of biological sciences · 2025
    Review
  4. Review
  5. Retinal Neurodegeneration in an Intraocular Pressure Fluctuation Rat Model.International journal of molecular sciences · 2024
    Article
  6. Article
  7. Article
  8. Inward rectifier potassium (Kir) channels in the retina: living our vision.American journal of physiology. Cell physiology · 2022
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rachel A FischerDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Abigail L RouxVanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee.
Lauren K WarehamVanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee.
Rebecca M SappingtonDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID 0000-0002-3136-9631
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Training in Vision ResearchT32EY007135 · NEI · VANDERBILT UNIVERSITY · PI GEOFFREY F WOODMAN · 1994 to 2026
$5.8M
Interleukin-6 and Retinal Ganglion Cell Degeneration in GlaucomaR01EY020496 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SAPPINGTON, REBECCA M · 2010 to 2020
$4.0M
Mapping Brain Activity with High Spatiotemporal Resolution using Graphene ProbesR01EY027729 · NEI · VANDERBILT UNIVERSITY · PI LI, DEYU · 2017 to 2021
$2.0M
Graphene Optoelectronic Probes for Mapping Electrical Activities in RetinaR21EY026176 · NEI · VANDERBILT UNIVERSITY · PI LI, DEYU, SAPPINGTON, REBECCA M · 2016 to 2017
$418k
NEI NIH HHS P30 EY008126NEI NIH HHS R01 EY020496NEI NIH HHS R01 EY027729NEI NIH HHS R21 EY026176NEI NIH HHS T32 EY007135
6 · The paper itself

Abstract

Glaucoma is the leading cause of blindness worldwide, resulting from degeneration of retinal ganglion cells (RGCs), which form the optic nerve. Prior to structural degeneration, RGCs exhibit physiological deficits. Müller glia provide homeostatic regulation of ions that supports RGC physiology through a process called K

Indexed as

Intraocular PressureMechanotransduction, CellularAnimalsCell DeathCells, CulturedDisease Models, AnimalEpendymoglial CellsGene Expression RegulationGlaucomaKineticsMaleMembrane PotentialsMice, Inbred C57BLPotassiumPotassium Channels, Inwardly RectifyingPotassium Channels, Tandem Pore DomainPotassiumPotassium Channels, Inwardly RectifyingPotassium Channels, Tandem Pore DomainglaucomaK2PK channelsKirK siphoningmicrobeadMüller gliaretina

Identifiers

PMID31166711
PMCPMC6732416
OpenAlexW2948390883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.