ArticleAmerican journal of physiology. Renal physiology2019
Effect of renal tubule-specific knockdown of the Na
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Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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0cells of the map it votes in
43citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 72 citations in OpenAlex.
- Dapagliflozin modulates plasma lipidomic profile and urinary metabolite excretion in type 2 diabetes.Cardiovascular diabetology · 2025Trial
- Effect of Dapagliflozin on Urine Metabolome in Patients with Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2021Trial
- Metabolic control by liver-kidney crosstalk and glucagon in health and disease.Nature reviews. Nephrology · 2026Review
- SGLT2i, anti-endothelin A and double endothelin and angiotensin inhibitors: a new future for chronic kidney disease in children.Pediatric nephrology (Berlin, Germany) · 2026Review
- Renal Tubule Cell-SpecificHypertension (Dallas, Tex. : 1979) · 2026Article
- Renal NHE3 is required to limit hypokalemia and metabolic acidosis during dietary potassium deficiency.Pflugers Archiv : European journal of physiology · 2026Article
- Neural Upregulation of SGLT2-MAP17-PDZK1 Complex in Kidneys of Rats With Heart Failure.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Histamine regulates the activity and the expression of the NaInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- ASK1 limits kidney glucose reabsorption, growth, and mid-late proximal tubule KIM-1 induction when diabetes and Western diet are combined with SGLT2 inhibition.American journal of physiology. Renal physiology · 2025Article
- Acetazolamide Therapy and Kidney Function in Persons with Nonalbuminuric Diabetes Mellitus Type 1.Journal of the American Society of Nephrology : JASN · 2025Article
- Kidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway.Diabetes & metabolism journal · 2025Article
- Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism.American journal of physiology. Renal physiology · 2025Article
- How can inhibition of glucose and sodium transport in the early proximal tubule protect the cardiorenal system?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Review
- The potential anti-arrhythmic effect of SGLT2 inhibitors.Cardiovascular diabetology · 2024Review
- Glycolytic lactate in diabetic kidney disease.JCI insight · 2024Article
- SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake.American journal of physiology. Renal physiology · 2024Article
- New functions and roles of the NaPflugers Archiv : European journal of physiology · 2024Review
- SGLT2i relieve proteinuria in diabetic nephropathy patients potentially by inhibiting renal oxidative stress rather than through AGEs pathway.Diabetology & metabolic syndrome · 2024Article
- Aristolochic acid-induced nephropathy is attenuated in mice lacking the neutral amino acid transporter BAmerican journal of physiology. Renal physiology · 2022Article
- Renoprotective Effects of SGLT2 Inhibitors.Heart failure clinics · 2022Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Akira OnishiDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Yiling FuDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Manjula DarshiCenter for Renal Precision Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Maria Crespo-MasipDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Winnie HuangDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Panai SongDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Rohit PatelDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Young Chul KimDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Josselin NespouxDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Brent FreemanDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Manoocher SoleimaniDepartment of Medicine, University of Cincinnati, Cincinnati, Ohio.
Scott ThomsonDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
Kumar SharmaCenter for Renal Precision Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Volker VallonDepartment of Medicine, University of California San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California.
University of California, San Diego · USThe University of Texas Health Science Center at San Antonio · USVA San Diego Healthcare System · USUniversity of Cincinnati · US
Funding
UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SANDERS, PAUL W. · 2008 to 2022
$18.3MGlomerular and Tubular Function in the Diabetic KidneyR01DK112042 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI SCOTT Culver THOMSON, Volker Vallon · 2017 to 2026
$4.1MRole of tubuloglomerular feedback in the development of hypertension in diabetesR01HL142814 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2019 to 2022
$2.4MUnraveling Kidney Physiology, Pathophysiology & Therapeutics: A Modeling ApproachR01DK106102 · NIDDK · DUKE UNIVERSITY · PI LAYTON, ANITA · 2016 to 2019
$1.4MThe Role of Intercalated Cells and Their Acid Base and Electrolyte Transport Machinery in Kidney Cystogenesis by Tuberous SclerosisI01BX001000 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI SOLEIMANI, MANOOCHER · 2012 to 2025
–BLRD VA I01 BX001000NHLBI NIH HHS R01 HL142814NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK106102NIDDK NIH HHS R01 DK112042
Abstract
Na
Indexed as
Acid-Base EquilibriumRenal ReabsorptionAmino Acids, Branched-ChainAmmoniaAnimalsBicarbonatesBiomarkersBlood GlucoseDiabetes Mellitus, Type 1Diabetic NephropathiesDisease Models, AnimalEnergy MetabolismGene Expression RegulationGene Knockdown TechniquesHydrogen-Ion ConcentrationKidney TubulesAmino Acids, Branched-ChainAmmoniaBicarbonatesBiomarkersBlood GlucoseSlc5a1 protein, mouseSlc5a2 protein, mouseSlc9a3 protein, mouseSodiumSodium-Glucose Transporter 1Sodium-Glucose Transporter 2Sodium-Hydrogen Exchanger 3albuminuriadiabetes mellitusdiabetic nephropathyhyperfiltrationNa-glucose cotransporter 2proximal tubuletubular growth
Identifiers
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Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.