Evidence map›Paper›PMID 31166705›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Expression and distribution of PIEZO1 in the mouse urinary tract.

Marianela G Dalghi, Dennis R Clayton, Wily G Ruiz, Mohammad M Al-Bataineh, Lisa M Satlin, Thomas R Kleyman, William A Ricke, Marcelo D Carattino, Gerard Apodaca

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 130 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. PIEZO1-mediated mechanosensation links aging to bladder dysfunction.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025
    Review
  14. CaAmerican journal of physiology. Cell physiology · 2025
    Article
  15. Diurnal regulation of urinary behavior and gene expression in aged mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  16. Review
  17. Piezo1, F-Actin Remodeling, and Podocyte Survival and Regeneration.Journal of the American Society of Nephrology : JASN · 2025
    Article
  18. Mechanotransduction and the Integrity of the Slit Diaphragm.Journal of the American Society of Nephrology : JASN · 2025
    Article
  19. Review
  20. Piezo, Nephrocyte Function, and Slit Diaphragm Maintenance in Drosophila.Journal of the American Society of Nephrology : JASN · 2025
    Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Marianela G DalghiDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
Dennis R ClaytonDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
Wily G RuizDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
Mohammad M Al-BatainehDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
Lisa M SatlinDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai , New York, New York.
Thomas R KleymanDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
William A RickeDepartment of Urology and George M. O'Brien Center for Research Excellence, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0002-9807-2090
Marcelo D CarattinoDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
Gerard ApodacaDepartment of Medicine and George M. O'Brien Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
University of Pittsburgh · USIcahn School of Medicine at Mount Sinai · USUniversity of Wisconsin–Madison · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI STRAND, DOUGLAS WILLIAM, VEZINA, CHAD M. · 2014 to 2023
$12.8M
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF DIOXINR01ES001332 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI PETERSON, RICHARD EUGENE, VEZINA, CHAD M. · 1985 to 2021
$5.3M
Role of PIEZO Channels in Bladder Function and DysfunctionR01DK119183 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L, CARATTINO, MARCELO DANIEL · 2019 to 2023
$3.0M
Role of Uroplakins in Urinary Tract Development and CAKUTR01DK104287 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2014 to 2018
$2.2M
Role of Muc1 in the b-catenin Response to Acute Kidney InjuryK01DK109038 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AL-BATAINEH, MOHAMMAD · 2016 to 2021
$798k
Role of the MUC1/HIF-1a Complex in the kidney proximal tubule during ischemia-reperfusion injury.R03DK131093 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AL-BATAINEH, MOHAMMAD · 2022 to 2023
$236k
NIDDK NIH HHS K01 DK109038NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK104287NIDDK NIH HHS R01 DK119183NIDDK NIH HHS R03 DK131093NIDDK NIH HHS U54 DK104310NIEHS NIH HHS R01 ES001332
6 · The paper itself

Abstract

The proper function of the organs that make up the urinary tract (kidneys, ureters, bladder, and urethra) depends on their ability to sense and respond to mechanical forces, including shear stress and wall tension. However, we have limited understanding of the mechanosensors that function in these organs and the tissue sites in which these molecules are expressed. Possible candidates include stretch-activated PIEZO channels (PIEZO1 and PIEZO2), which have been implicated in mechanically regulated body functions including touch sensation, proprioception, lung inflation, and blood pressure regulation. Using reporter mice expressing a COOH-terminal fusion of

Indexed as

AnimalsFemaleGene Expression RegulationGenes, ReporterIon ChannelsMaleMechanotransduction, CellularMice, Inbred C57BLMice, TransgenicPressureStress, MechanicalTissue DistributionUrinary TractIon ChannelsPiezo1 protein, mousebladderkidneymechanotransductionPIEZO channelurinary tract

Identifiers

PMID31166705
PMCPMC6732449
OpenAlexW2948846227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.