Evidence map›Paper›PMID 31166701›Full record

ArticleThe American journal of sports medicine2019

Changes in Cross-sectional Area and Signal Intensity of Healing Anterior Cruciate Ligaments and Grafts in the First 2 Years After Surgery.

Ata M Kiapour, Kirsten Ecklund, Martha M Murray, BEAR Trial Team, Brett Flutie, Christina Freiberger, Rachael Henderson, Dennis Kramer, Lyle Micheli, Laura Thurber and 2 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of sports medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02292004 (Bridge-Enhanced ACL Repair-Safety Study), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02292004 naactive not recruitingnot on this map

Bridge-Enhanced ACL Repair-Safety Study

TypeinterventionalSponsorMiach OrthopaedicsRan2015 to 2026Enrolled20ConditionsAnterior Cruciate Ligament Injury, Anterior Cruciate Ligament TearArmsACL Repair with MIACH Scaffold, Standard ACL Reconstruction
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ata M KiapourInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Kirsten EcklundInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Martha M MurrayInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
BEAR Trial TeamInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Brett FlutieInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Christina FreibergerInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Rachael HendersonInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Dennis KramerInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Lyle MicheliInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Laura ThurberInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Yi-Meng YenInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Braden C FlemingInvestigation performed at Boston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · US

Funding

Pilot Projects ProgramP30GM122732 · NIGMS · RHODE ISLAND HOSPITAL · PI CRISCO, JOSEPH J · 2017 to 2021
$6.6M
Biologically Enhanced Healing of Autograft ACL Reconstruction.R01AR056834 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2009 to 2017
$5.8M
Non-invasive Assessment of Ligament Healing, in VivoR01AR065462 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2014 to 2016
$2.1M
NIAMS NIH HHS R01 AR056834NIAMS NIH HHS R01 AR065462NIGMS NIH HHS P30 GM122732
6 · The paper itself

Abstract

backgroundThe quality of a repaired anterior cruciate ligament (ACL) or reconstructed graft is typically quantified in clinical studies by evaluating knee, lower extremity, or patient performance. However, magnetic resonance imaging of the healing ACL or graft may provide a more direct measure of tissue quality (ie, signal intensity) and quantity (ie, cross-sectional area). HYPOTHESES: (1) Average cross-sectional area or signal intensity of a healing ACL after bridge-enhanced ACL repair (BEAR) or a hamstring autograft (ACL reconstruction) will change postoperatively from 3 to 24 months. (2) The average cross-sectional area and signal intensity of the healing ligament or graft will correlate with anatomic features of the knee associated with ACL injury. STUDY

designCohort study; Level of evidence, 2.

methodsPatients with a complete midsubstance ACL tear who were treated with either BEAR (n = 10) or ACL reconstruction (n = 10) underwent magnetic resonance imaging at 3, 6, 12, and 24 months after surgery. Images were analyzed to determine the average cross-sectional area and signal intensity of the ACL or graft at each time point. ACL orientation, stump length, and bony anatomy were also assessed.

resultsMean cross-sectional area of the grafts was 48% to 98% larger than the contralateral intact ACLs at all time points (

conclusionHamstring autografts were larger in cross-sectional area and more vertically oriented than the native ACLs at 24 months after surgery. BEAR ACLs had a cross-sectional area, signal intensity, and sagittal orientation similar to the contralateral ACLs at 24 months. The early signal intensity and cross-sectional area of the repaired ACL may be affected by specific anatomic features, including lateral tibial slope and notch width-observations that deserve further study in a larger cohort of patients. REGISTRATION: NCT02292004 (ClinicalTrials.gov identifier).

Indexed as

Anterior Cruciate LigamentAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionAutograftsCohort StudiesFemaleHamstring MusclesHumansKnee JointMagnetic Resonance ImagingMalePostoperative PeriodTransplantation, AutologousYoung AdultACLBEARbridge-enhanced ACL repairMRIreconstructionrepairsignal intensitysize

Identifiers

PMID31166701
PMCPMC6599545
OpenAlexW2948236295

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.