Evidence map›Paper›PMID 31166692›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

Renal nerves and leukocyte infiltration in the kidney during salt-sensitive hypertension.

Ammar J Alsheikh, Hayley Lund, John Henry Dasinger, Justine M Abais-Battad, Daniel J Fehrenbach, David L Mattson

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. CCL2 mediates early renal leukocyte infiltration during salt-sensitive hypertension.American journal of physiology. Renal physiology · 2020
    Article
  8. Inflammatory macrophages in the kidney contribute to salt-sensitive hypertension.American journal of physiology. Renal physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ammar J AlsheikhDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Hayley LundDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
John Henry DasingerDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Justine M Abais-BattadDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Daniel J FehrenbachDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.ORCID 0000-0003-3382-464X
David L MattsonDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Medical College of Wisconsin · US

Funding

Therapeutic Effects of mTOR Inhibition in Salt-Sensitive HypertensionP01HL116264 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MATTSON, DAVID L. · 2013 to 2021
$18.7M
INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Mechanisms of renal immune cell infiltration in salt-sensitive hypertensionR01HL137748 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI COWLEY, ALLEN W, MATTSON, DAVID L. · 2018 to 2021
$2.3M
NHLBI NIH HHS P01 HL116264NHLBI NIH HHS R01 HL137748NHLBI NIH HHS T32 HL007852
6 · The paper itself

Abstract

Based on previous studies suggesting a role of renal nerves in renal inflammation, the present studies were performed to test the hypothesis that renal nerves mediate renal damage in Dahl salt-sensitive (SS) hypertension by increasing renal leukocyte infiltration. Experiments were performed in Dahl SS rats with bilateral renal denervation (RDN) and bilateral sham operation (

Indexed as

AnimalsBlood PressureHypertensionKidneyLeukocytesRandom AllocationRatsRats, Inbred DahlSodium Chloride, DietarySodium Chloride, DietaryDahl salt-sensitive rathypertensionleukocytesrenal damagerenal nerves

Identifiers

PMID31166692
PMCPMC6692755
OpenAlexW2948642418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.