Evidence map›Paper›PMID 31166001›Full record

ArticleJournal of molecular neuroscience : MN2019

Involvement of A

Grazia Maugeri, Agata Grazia D'Amico, Concetta Federico, Salvatore Saccone, Salvatore Giunta, Sebastiano Cavallaro, Velia D'Agata

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Adenosine AFEBS open bio · 2025
    Article
  2. Species dependence of APurinergic signalling · 2023
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Grazia MaugeriSection of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 87, 95123, Catania, Italy.
Agata Grazia D'AmicoDepartment of Human Science and Promotion of Quality of Life, San Raffaele Open University, Rome, Italy.
Concetta FedericoDepartment of Biological, Geological and Environmental Sciences, Section of Animal Biology, University of Catania, Catania, Italy.
Salvatore SacconeDepartment of Biological, Geological and Environmental Sciences, Section of Animal Biology, University of Catania, Catania, Italy.
Salvatore GiuntaSection of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 87, 95123, Catania, Italy.
Sebastiano CavallaroInstitute of Neurological Sciences, National Research Council, Catania, Italy.
Velia D'AgataSection of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia, 87, 95123, Catania, Italy. vdagata@unict.it.ORCID http://orcid.org/0000-0003-1114-8265
University of Catania · ITInstitute of Neurological Sciences · ITSan Raffaele University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. The clinical course may range from spontaneous regression towards ganglioneuroblastoma/ganglioneuroma or maturation to a very aggressive form characterized by an extensive hypoxic area. In solid tumors, extracellular microenvironment hypoxia induces the transcription of hypoxia-inducible factors (HIFs) leading to synthesis of pro-angiogenic factor, VEGF; also, it increases extracellular adenosine production from ATP breakdown. To date, the role of this nucleoside in the hypoxic/angiogenic pathway characterizing the core of cancer mass has not been investigated yet. Therefore, the aim of the present study was to analyze the adenosine effect on modulation of the HIF-1α/2α/VEGF pathway mediated through A

Indexed as

AdenosineAdenosine A3 Receptor AgonistsAdenosine A3 Receptor AntagonistsBasic Helix-Loop-Helix ProteinsBrain NeoplasmsCell HypoxiaCell Line, TumorEndothelial PAS Domain-Containing Protein 1HumansHypoxia-Inducible Factor 1, alpha SubunitMAP Kinase Signaling SystemNeuroblastomaReceptor, Adenosine A3Vascular Endothelial Growth Factor AAdenosineAdenosine A3 Receptor AgonistsAdenosine A3 Receptor AntagonistsBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1HIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitN(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosineReceptor, Adenosine A3Vascular Endothelial Growth Factor AA3 receptorAdenosineHypoxia-inducible factorsNeuroblastomaVascular endothelial growth factor

Identifiers

PMID31166001
OpenAlexW2962273887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.