Evidence map›Paper›PMID 31165996›Full record

ReviewPathology oncology research : POR2020

The Small Bowel Cancer Incidence Enigma.

Paulo Assumpção, André Khayat, Taíssa Araújo, Williams Barra, Geraldo Ishak, Aline Cruz, Sidney Santos, Ândrea Santos, Samia Demachki, Paula Assumpção and 8 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pathology oncology research : POR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Observational
  5. Frontiers in medicine · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Paulo AssumpçãoNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil. assumpcaopp@gmail.com.
André KhayatNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Taíssa AraújoNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Williams BarraNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Geraldo IshakNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Aline CruzNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Sidney SantosNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Ândrea SantosNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Samia DemachkiNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Paula AssumpçãoPrograma de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Belém, 66075-110, Brazil.
Danielle CalcagnoNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Ney SantosNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
Mônica AssumpçãoServiço de Endoscopia Digestiva, Hospital Universitário João de Barros Barreto, Belém, 66073-000, Brazil.
Fabiano MoreiraNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, 66073-000, Brazil.
André SantosPrograma de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Belém, 66075-110, Brazil.
Carolina AssumpçãoServiço de Cirurgia Oncológica, Hospital Alemão Oswaldo Cruz, São Paulo, 01327-001, Brazil.
Gregory RigginsDepartment of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD, 21287, USA.
Rommel BurbanoLaboratório de Biologia Molecular, Hospital Ophir Loyola, Belém, 66060-281, Brazil.
Universidade Federal do Pará · BRHospital Alemão Oswaldo Cruz · BRJohns Hopkins Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the small bowel is a vast organ with a highly proliferative epithelium, the incidence of small bowel cancers is surprisingly low. Many factors could be involved in this unexpected cancer incidence, including difficult access to the exploration of the small bowel mucosa, which might lead to missed diagnoses of non-obstructive and non-bleeding small tumours. Moreover, possible factors that influence the low incidence include more efficient machinery of DNA replication and DNA repair enzymes, peculiarities in microbiota components, competence of the immune system, and the speed of intestinal transit. Importantly, the answer for the enigmatic risk of driver mutations caused by replication errors may be hidden in the small bowel, which is an obscure part of digestive tract that is usually inaccessible by endoscopic or colonoscopic conventional investigations. These observations warrant the necessity of an urgent exploration of small bowel features, including the evaluation of DNA replication controls and expression of DNA repair genes, in order to shed light on these obscure events.

Indexed as

HumansIncidenceIntestinal NeoplasmsIntestine, SmallDNA repairEnigmaLow incidenceSmall bowel cancer

Identifiers

PMID31165996
OpenAlexW2961360438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.