ArticleJournal of the American Heart Association2019
Age at Menarche and Risk of Cardiovascular Disease Outcomes: Findings From the National Heart Lung and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Brazilian Guideline on Menopausal Cardiovascular Health - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Early Menarche as a Protective Factor Against Cardiovascular Events: A Systematic Review and Meta-analysis.Anatolian journal of cardiology · 2024Pooled it
- The J shaped association of age at menarche and cardiovascular events: systematic review and meta-analysis.Scientific reports · 2024Pooled it
- A Systematic Literature Review of Factors Affecting the Timing of Menarche: The Potential for Climate Change to Impact Women's Health.International journal of environmental research and public health · 2020Pooled it
- Early in, early out: reproductive lifespan timing and cardiometabolic risk in women.Journal of endocrinological investigation · 2026Review
- Female Cardiovascular Health After Childhood Cancer.Current cardiology reports · 2026Review
- Age at Menarche and the Risk of Cardiac Events in Women With Congenital Long QT Syndrome.Journal of the American Heart Association · 2026Article
- Age at menarche and adverse pregnancy and perinatal outcomes: triangulating evidence from multivariable and Mendelian randomization analyses.International journal of epidemiology · 2026Article
- Early menarche and late menopause and their association with hypertension among Bangladeshi women: a community-based cross-sectional study in Dhaka, Bangladesh.BMC women's health · 2026Article
- Sex Differences in Atherosclerosis and its Clinical Complications.Current atherosclerosis reports · 2026Review
- Age at menarche and blood pressure in late adolescence: the role of body adiposity in a Brazilian birth cohort.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2026Article
- Age at Menarche and Its Association with Cardiovascular Disease in Women with Childhood-Onset Type 1 Diabetes (T1D).Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- A Review of Traditional and Non-Traditional Cardiovascular Risk Factors in Women.International journal of women's health · 2026Review
- Menopause Hormone Therapy in Women With Cardiovascular Risk Factors or Established Ischemic Heart Disease: A Joint FIGO and WHF Position Paper.Global heart · 2026Review
- Position Statement on Cardiometabolic Health Across the Woman's Life Course - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Age at Menarche and Coronary Artery Disease Risk: Divergent Associations With Different Sources of Variation.The Journal of clinical endocrinology and metabolism · 2025Article
- The Particularities of Arterial Hypertension in Female Sex: From Pathophysiology to Therapeutic Management.Journal of clinical medicine · 2025Review
- Association of Age at Menarche With Inflammation and Glucose Metabolism Biomarkers in US Adult Women: NHANES 1999-2018.The Journal of clinical endocrinology and metabolism · 2025Article
- Myocardial Infarction in the Young: Aetiology, Emerging Risk Factors, and the Role of Novel Biomarkers.Journal of cardiovascular development and disease · 2025Review
- Age at menarche is inversely related to the prevalence of uterine cancer.European journal of medical research · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
Background Previous studies have reported an association between the timing of menarche and cardiovascular disease ( CVD ). However, emerging studies have not examined the timing of menarche in relation to role of estrogen over a lifetime and major adverse cardiac events ( MACE ). Methods and Results A total of 648 women without surgical menopause undergoing coronary angiography for suspected ischemia in the WISE (Women's Ischemia Syndrome Evaluation) study were evaluated at baseline and followed for 6 years (median) to assess major adverse CVD outcomes. MACE was defined as the first occurrence of all-cause death, nonfatal myocardial infarction, nonfatal stroke, or heart failure hospitalization. Age at menarche was self-reported and categorized (≤10, 11, 12, 13, 14, ≥15 years) with age 12 as reference. Total estrogen time and supra-total estrogen time were calculated. Cox regression analysis was performed adjusting for CVD risk factors. Baseline age was 57.9 ± 12 years (mean ± SD ), body mass index was 29.5 ± 6.5 kg/m
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.