ArticleBrain and behavior2019
Disruptions of the olfactory and default mode networks in Alzheimer's disease.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Valid olfactory impairment tests can help identify mild cognitive impairment: an updated meta-analysis.Frontiers in aging neuroscience · 2024Pooled it
- Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer's disease expressing humanized APOEε4 and Trem2*R47H.Frontiers in aging neuroscience · 2026Article
- The olfactory functional network in the Alzheimer's disease continuum: a resting state fMRI study.Frontiers in aging neuroscience · 2025Article
- Assessment of sensory impairment in older adults with dementia.Journal of otology · 2024Article
- Odor identification score as an alternative method for early identification of amyloidogenesis in Alzheimer's disease.Scientific reports · 2024Article
- Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders.Frontiers in neuroscience · 2024Review
- Olfactory deficit: a potential functional marker across the Alzheimer's disease continuum.Frontiers in neuroscience · 2024Review
- A Pilot Study of Short-Course Oral Vitamin A and Aerosolised Diffuser Olfactory Training for the Treatment of Smell Loss in Long COVID.Brain sciences · 2023Article
- Common and unique dysconnectivity profiles of dorsal and median raphe in Parkinson's disease.Human brain mapping · 2023Article
- Abnormal metabolic connectivity in default mode network of right temporal lobe epilepsy.Frontiers in neuroscience · 2023Article
- Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction.Brain sciences · 2022Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Functional Connectivity of the Chemosenses: A Review.Frontiers in systems neuroscience · 2022Review
- Developmental Profile of Brain Neprilysin Expression Correlates with Olfactory Behaviour of Rats.Journal of molecular neuroscience : MN · 2021Article
- Volumetry of Olfactory Structures in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and a Meta-Analysis.Brain sciences · 2021Review
- Olfactory impairment in men and mice related to aging and amyloid-induced pathology.Pflugers Archiv : European journal of physiology · 2021Review
- Odorant-induced brain activation as a function of normal aging and Alzheimer's disease: A preliminary study.Behavioural brain research · 2021Article
- Chemosensory Systems in COVID-19: Evolution of Scientific Research.ACS chemical neuroscience · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionOlfactory deficits are prevalent in early Alzheimer's disease (AD) and are predictive of progressive memory loss and dementia. However, direct neural evidence to relate AD neurodegeneration to deficits in olfaction and memory is limited.
methodsWe combined the University of Pennsylvania Smell Identification Test (UPSIT) with olfactory functional magnetic resonance imaging (fMRI) to investigate links between neurodegeneration, the olfactory network (ON) and the default mode network (DMN) in AD.
resultsBehaviorally, olfactory and memory scores showed a strong positive correlation in the study cohorts. During olfactory fMRI, the ON showed reduced task-related activation and the DMN showed reduced task-related suppression in mild cognitive impairment (MCI) and AD subjects compared to age-matched cognitively normal subjects.
conclusionsThe results provide in vivo evidence for selective vulnerability of ON and DMN in AD and significantly improves the viable clinical applications of olfactory testing. A network-based approach, focusing on network integrity rather than focal pathology, seems beneficial to olfactory prediction of dementia in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.