Observational studyJournal of internal medicine2019
Natural history of prediabetes in older adults from a population-based longitudinal study.
Observational study in Journal of internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 88 citations in OpenAlex.
- Risk of progression to type 2 diabetes or regression to normoglycaemia among Ghanaians with prediabetes living in Ghana and the Netherlands: The RODAM prospective study.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Real-world predictors of progression to type 2 diabetes among adults with prediabetes.Diabetes, obesity & metabolism · 2026Article
- Impact of control patterns for the atherogenic index of plasma and its obesity-associated indices on transitions in prediabetes glycemic status: results from the CHARLS national cohort study.Lipids in health and disease · 2026Observational
- Quantitative metabolomics and machine learning identify differential metabolomic biomarkers across normoglycaemia, pre-diabetes and diabetes in a Qinghai Plateau population.BMJ public health · 2026Article
- A predictive study of glycaemic reversal in Chinese individuals with prediabetes based on machine learning: a 5-year cohort study.Frontiers in endocrinology · 2026Article
- Epidemiological features and prevalence patterns of prediabetes outcomes in an east coast Malaysian cohort: A retrospective cohort study.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2026Article
- Trends of diabetes and pre-diabetes in Indonesia 2013-2023: a serial analysis of national health surveys.BMJ open · 2025Article
- Association of remnant cholesterol with progression and regression of prediabetes in middle-aged and older adults: a nationwide cohort study.Acta diabetologica · 2025Article
- Factors related to reversal of prediabetes in patients from a cardiovascular risk program during 2019 - 2023.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Thirty-Year Glycemic Trajectories From Young Adulthood Through Middle Age.JAMA network open · 2025Article
- Association between atherogenicity indices and prediabetes: a 5-year retrospective cohort study in a general Chinese physical examination population.Cardiovascular diabetology · 2025Article
- Development of a 5-Year Risk Prediction Model for Transition From Prediabetes to Diabetes Using Machine Learning: Retrospective Cohort Study.Journal of medical Internet research · 2025Article
- The role of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (nhhr) in prediabetes progression and the mediating effect of BMI: a longitudinal study in China.Diabetology & metabolic syndrome · 2025Article
- The joint effect of cumulative metabolic parameters on the risk of type 2 diabetes: a population-based cohort study.Nutrition & metabolism · 2024Article
- Diabetes, Prediabetes, and Brain Aging: The Role of Healthy Lifestyle.Diabetes care · 2024Article
- Exposure of cumulative atherogenic index of plasma and the development of prediabetes in middle-aged and elderly individuals: evidence from the CHARLS cohort study.Cardiovascular diabetology · 2024Article
- Article
- Different levels of physical activity and risk of developing type 2 diabetes among adults with prediabetes: a population-based cohort study.Nutrition journal · 2024Article
- Pros and cons of live kidney donation in prediabetics: A critical review and way forward.World journal of transplantation · 2024Review
- Serum adiponectin and peroxisome proliferator-activated receptors-γ levels in obese patients with and without prediabetes.Revista da Associacao Medica Brasileira (1992) · 2024Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe natural history of prediabetes in older adults remains unknown.
objectivesTo assess the rate at which prediabetes progresses to diabetes, leads to death or reverts to normoglycaemia in older adults and to identify prognostic factors related to different outcomes of prediabetes.
methodsIn the Swedish National Study on Aging and Care-Kungsholmen, 2575 diabetes-free participants aged ≥60 years were examined at baseline and followed for up to 12 years. At each wave, diabetes was diagnosed via medical examination, antidiabetic drug use, medical records or glycated haemoglobin (HbA1c) ≥6.5%. Prediabetes was defined as HbA1c ≥5.7% and normoglycaemia as HbA1c <5.7% in diabetes-free participants. Data were analysed with multinomial logistic regression.
resultsAt baseline, 918 (36%) individuals had prediabetes. Of them, 204 (22%) reverted to normoglycaemia (3.4/100 person-years, 95% CI 5.6-12.3), 119 (13%) developed diabetes (2.0/100 person-years, 95% CI 1.7-2.4) and 215 (23%) died (13.0/100 person-years, 95% CI 11.4-14.9) during the 12-year follow-up. The rates of reversion, progression and mortality were higher in the first 6-year than in the second 6-year follow-up, albeit not statistically significant. Lower systolic blood pressure (SBP), absence of heart diseases and weight loss promoted the reversion from prediabetes to normoglycaemia, whilst obesity accelerated its progression to diabetes.
conclusionsDuring a 12-year follow-up, most of older adults with prediabetes remained stable or reverted to normoglycaemia, whereas only one-third developed diabetes or died. Lower SBP, no heart diseases and weight management may promote reversion to normoglycaemia, suggesting possible strategies for achieving normoglycaemia in older adults with prediabetes.
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