Evidence map›Paper›PMID 31165556›Full record

ArticleAdvanced healthcare materials2019

Real-Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles.

Wataru Katagiri, Jeong Heong Lee, Marc-André Tétrault, Homan Kang, Sinyoung Jeong, Conor L Evans, Shinya Yokomizo, Sheena Santos, Catherine Jones, Shuang Hu and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Potentiating the Efficacy of mRNA Vaccines through NIR-II Imaging-Guided Precise Vaccination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Article
  3. Article
  4. Multimodality imaging of nanoparticle-based vaccines: Shedding light on immunology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022
    Review
  5. NIR fluorescence imaging and treatment for cancer immunotherapy.Journal for immunotherapy of cancer · 2022
    Review
  6. Article
  7. Near-infrared fluorescence imaging in immunotherapy.Advanced drug delivery reviews · 2020
    Review
  8. Targeted Near-Infrared Fluorescence Imaging for Regenerative Medicine.Tissue engineering and regenerative medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Wataru KatagiriGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Jeong Heong LeeGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Marc-André TétraultGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Homan KangGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Sinyoung JeongWellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Conor L EvansWellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Shinya YokomizoGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Sheena SantosGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Catherine JonesGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Shuang HuGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Georges El FakhriGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Kosuke TsukadaGraduate School of Science and Technology, Keio University, 3-14-1 Hiyoshi, Yokohama, Kanagawa, 223-8522, Japan.
Hak Soo ChoiGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
Satoshi KashiwagiGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.ORCID 0000-0001-8910-3257
Gordon Center for Medical Imaging · USKeio University · JPMassachusetts General Hospital · US

Funding

Mucins and immune cell interactions in ovarian cancer pathogenesis & progressionR35CA197605 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CRAMER, DANIEL WILLIAM · 2016 to 2022
$6.9M
Image-Guided Drug Delivery for Pancreatic Neuroendocrine Tumor.R01EB022230 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CHOI, HAK SOO, HENARY, MAGED M · 2017 to 2020
$3.6M
Near-infrared laser to replace chemical vaccine adjuvantR01AI105131 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI KASHIWAGI, SATOSHI · 2013 to 2016
$1.7M
Laser-based non-invasive immunotherapy for food allergyR21AI144103 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI KASHIWAGI, SATOSHI · 2019 to 2020
$433k
NCI NIH HHS R35 CA197605NIAID NIH HHS R01 AI105131NIAID NIH HHS R21 AI144103NIBIB NIH HHS R01 EB022230
6 · The paper itself

Abstract

Efficient and timely delivery of vaccine antigens to the secondary lymphoid tissue is crucial to induce protective immune responses by vaccination. However, determining the longitudinal biodistribution of injected vaccines in the body has been a challenge. Here, the near-infrared (NIR) fluorescence imaging is reported that can efficiently enable the trafficking and biodistribution of vaccines in real time. Zwitterionic NIR fluorophores are conjugated on the surface of model vaccines and tracked the fate of bioconjugated vaccines after intradermal administration. Using an NIR fluorescence imaging system, it is possible to obtain time-course imaging of vaccine trafficking through the lymphatics, observing notable uptake in lymph nodes with minimal nonspecific tissue interactions. Flow cytometry analysis confirmed that the uptake in lymph nodes by antigen presenting cells was highly dependent on the hydrodynamic diameter of vaccines. These results demonstrate that the combination of a real-time NIR fluorescence imaging system and zwitterionic fluorophores is a powerful tool to determine the fate of vaccine antigens. Since such non-specific vaccine uptake causes serious adverse reactions, this method is not only useful for optimization of vaccine design, but also for safety evaluation of clinical vaccine candidates.

Indexed as

AnimalsAntigen-Presenting CellsFluorescent DyesIonsLymph NodesMiceModels, BiologicalNanoparticlesOvalbuminQuaternary Ammonium CompoundsSilicon DioxideSpectroscopy, Near-InfraredSulfonic AcidsTissue DistributionVaccinesFluorescent DyesIonsOvalbuminQuaternary Ammonium CompoundsSilicon DioxideSulfonic AcidsVaccinesZW800-1 compoundbiodistributionhydrodynamic diametersnear-infrared imagingvaccineszwitterionic fluorophores

Identifiers

PMID31165556
PMCPMC6687515
OpenAlexW2956177199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.