ArticleAlimentary pharmacology & therapeutics2019
Gastric bypass surgery in the treatment of gastro-oesophageal reflux symptoms.
Article in Alimentary pharmacology & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Gastro-Oesophageal Reflux Disease Outcomes Following Roux-en-Y Gastric Bypass Surgery in Patients with Obesity: A Systematic Review and Meta-analysis.Obesity surgery · 2025Pooled it
- Magnetic Sphincter Augmentation After Gastric Surgery.JSLS : Journal of the Society of Laparoendoscopic SurgeonsPooled it
- Efficacy and Safety of Fundoplication Sleeve Gastrectomy in Obesity and GERD: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Is Roux-en-Y gastrojejunostomy an adequate anti-reflux operation after esophagogastric myotomy?Surgical endoscopy · 2025Article
- Impact of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Esophageal Physiology and Gastroesophageal Reflux Disease: A Prospective Study.Obesity surgery · 2025Article
- Gastroesophageal reflux disease symptoms after sleeve gastrectomy with anterior hemifundoplication: a pilot study.ANZ journal of surgery · 2025Article
- Comparative analysis of metabolic and bariatric surgery outcomes and complications in patients under and over 50 years of age.Langenbeck's archives of surgery · 2025Article
- Gastroesophageal reflux disease related to laparoscopic sleeve gastrectomy.Mini-invasive surgery · 2025Article
- Conversion of sleeve gastrectomy to Roux-en-Y gastric bypass: impact on reflux and weight loss.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2024Article
- Y Not Roux-en-Y?: Resolution of Barrett's Esophagus After Surgical Conversion of Gastric Sleeve in Two Patients.Digestive diseases and sciences · 2023Article
- Clinical influence of conversion of laparoscopic sleeve gastrectomy to one anastomosis gastric bypass on gastroesophageal reflux disease.Langenbeck's archives of surgery · 2023Article
- Multi-society consensus conference and guideline on the treatment of gastroesophageal reflux disease (GERD).Surgical endoscopy · 2023Article
- Turnkey algorithmic approach for the evaluation of gastroesophageal reflux disease after bariatric surgery.Gastroenterology report · 2023Review
- Factors Associated with Increased Severity of Erosive Esophagitis 1 Year After Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2022Article
- Risk of gastric and oesophageal adenocarcinoma following discontinuation of long-term proton-pump inhibitor therapy.Journal of gastroenterology · 2022Article
- Evaluation of the outcome of a proposed more physiological bypass surgery technique in morbid obesity: Long term 3 years follows up.Annals of medicine and surgery (2012) · 2022Article
- Hiatal reconstruction is safe and effective for control of reflux after laparoscopic sleeve gastrectomy.BMC surgery · 2022Article
- GASTROESOPHAGEAL SYMPTOMS AFTER LAPAROSCOPIC GASTRIC BYPASS: MISTAKES IN PERFORMING THE PROCEDURE?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022Article
- Gastroesophageal reflux related changes after sleeve gastrectomy and sleeve gastrectomy with fundoplication: A retrospective single center study.Frontiers in endocrinology · 2022Article
- ANTI-REFLUX PROCEDURES AFTER ROUX-EN-Y GASTRIC BYPASS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundGastric bypass is considered an effective treatment of co-existing gastro-oesophageal reflux (GERD) and obesity. Previous studies have had small sample sizes, short follow-up or substantial loss to follow-up.
aimTo assess the long-term risk of remaining/recurring reflux symptoms after gastric bypass.
methodsThis was a nationwide cohort study of all adults with preoperative reflux who underwent gastric bypass in Sweden between 2006 and 2015, with complete follow-up through 2016. The outcome was remaining/recurring reflux symptoms, defined as use of proton pump inhibitors or histamine-2 receptor antagonists for >6 months after surgery. Cumulative incidence and risk factors of reflux were assessed with multivariable Poisson regression.
resultsAmong 2454 participants (81.7% female; mean age: 46.1 years, SD: 9.8 years), who were followed for median 4.6 years (interquartile range: 3.1-6.3 years), reflux recurred in 48.8% (95% confidence interval [95% CI], 46.8-51.0) of participants within 2 years of gastric bypass and remained stable up to 10 years after surgery (yearly change in incidence rate ratio [IRR] of 1.00; 95% CI, 0.99-1.02). Risk factors for recurring reflux were high preoperative dose of anti-reflux medication (IRR 1.77; 95% CI, 1.60-1.96 compared with low dose), older age (IRR 1.12; 95% CI 1.02-1.24 comparing age >50 with <40 years), female sex (IRR 1.28; 95% CI, 1.16-1.42) and comorbidity (IRR 1.26; 95% CI, 1.14-1.39 comparing Charlson Comorbidity Index ≥2 with 0).
conclusionsReflux symptoms decrease rapidly after gastric bypass, but around half of operated patients require continuous anti-reflux medication. The treatment efficacy of gastric bypass on reflux symptoms might have been overestimated.
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