Evidence map›Paper›PMID 31165490›Full record

ArticleBritish journal of clinical pharmacology2019

Nonmedical use of alprazolam in the UK: Results from a nationally representative survey.

Joanna Hockenhull, Elise Amioka, Joshua C Black, Colleen M Haynes, Paul I Dargan, Richard C Dart, David M Wood

Abstract read
In one paragraph

Article in British journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Alprazolam-related deaths in Scotland, 2004-2020.Journal of psychopharmacology (Oxford, England) · 2022
    Article
  3. GABAFrontiers in psychiatry · 2022
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joanna HockenhullClinical Toxicology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.ORCID 0000-0002-3361-7598
Elise AmiokaRocky Mountain Poison & Drug Center, Denver Health and Hospital Authority, Denver, CO, 80204, USA.
Joshua C BlackRocky Mountain Poison & Drug Center, Denver Health and Hospital Authority, Denver, CO, 80204, USA.
Colleen M HaynesRocky Mountain Poison & Drug Center, Denver Health and Hospital Authority, Denver, CO, 80204, USA.
Paul I DarganClinical Toxicology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Richard C DartRocky Mountain Poison & Drug Center, Denver Health and Hospital Authority, Denver, CO, 80204, USA.
David M WoodClinical Toxicology, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is concern in the UK about nonmedical use (NMU) of alprazolam (Xanax). We investigated the epidemiology of alprazolam NMU compared with diazepam using data from the Survey of Non-Medical Use of Prescription Drugs (NMURx) programme (collected 28 September-1 December 2017). The survey included 10 019 respondents and was weighted by age, sex and region to represent 52 927 659 UK adults. The estimated national prevalence of lifetime NMU of alprazolam was 0.32% (95% confidence interval: 0.19-0.46), and 1.30% (1.06-1.54) for diazepam. The prevalence of NMU in the last 90 days was significantly different when split by age category for alprazolam (P < .001), but not for diazepam (P = .262) with alprazolam NMU being more common among younger adults (age 16-24 years: 0.37%; age 25-34 years: 0.14%; 35 years or older: 0.01%). Further research is needed to fully understand the motivations of alprazolam NMU and to monitor whether the popularity of alprazolam will rise.

Indexed as

MotivationAdolescentAdultAgedAge FactorsAlprazolamCentral Nervous System StimulantsChildCross-Sectional StudiesDiazepamFemaleHumansMaleMiddle AgedPrescription Drug MisusePrevalenceAlprazolamCentral Nervous System StimulantsDiazepamaddictiondrug abusepublic health

Identifiers

PMID31165490
PMCPMC6624393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.