ArticleClinical journal of gastroenterology2019
Gastric adenocarcinoma of fundic gland type arising from heterotopic gastric glands during a 19-year follow-up period.
Article in Clinical journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Feasibility study of cap-assisted endoscopic mucosal resection for gastric adenocarcinoma of fundic gland type.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Diagnostic challenges of rarely well-differentiated adenocarcinoma of the stomach.Pathology oncology research : POR · 2025Article
- Case report and literature analysis of ectopic gastric glands combined with intestinal-type gastric cancer in an HP-negative background.Frontiers in oncology · 2025Article
- Gastric dysplasia arising from a submucosal heterotopic gastric gland.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Gastric adenocarcinoma of the fundic gland type: A review of the literature.JGH open : an open access journal of gastroenterology and hepatology · 2023Review
- A case of early gastric cancer resembling a subepithelial lesion diagnosed by endoscopic ultrasound-guided fine needle aspiration.Clinical journal of gastroenterology · 2022Article
- Successful resection of gastric cancer arising from a heterotopic gastric gland in the submucosa by endoscopic submucosal dissection.Clinical case reports · 2022Article
- Gastric adenocarcinoma arising from hamartomatous inverted polyp during 8-year follow-up.DEN open · 2022Article
- Gastric adenocarcinoma of the fundic gland: A review of clinicopathological characteristics, treatment and prognosis.Rare tumors · 2021Review
- Gastric adenocarcinoma appearance in leiomyoma: A case report.International journal of surgery case reports · 2020Article
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Abstract
A 73-year-old man with prior history of duodenal ulcer has been undergoing periodic upper gastrointestinal endoscopy since 1999. In 2017, a 25-mm submucosal tumor-like protrusion was detected in the lesser curvature of the upper stomach; histological examination of the lesion revealed gastric adenocarcinoma of fundic gland type. En bloc resection was achieved using endoscopic submucosal dissection. The patient was histopathologically diagnosed with gastric adenocarcinoma of fundic gland type arising from heterotopic gastric glands. Immunohistochemical staining was positive for MUC5AC, MUC6, pepsinogen I, and proton pump but negative for MUC2 and CD10. Moreover, the patient's Ki-67 labeling index score was extremely low. The presence of MUC5AC indicated that the tumor differentiated to the foveolar epithelium and fundic glands. Gastric adenocarcinoma of fundic gland type that differentiates to several directions has a higher malignant potential than the disease that differentiates to chief cells. A retrospective review of the patient's previous endoscopic examination revealed that the submucosal tumor-like protrusion existed since 2000; tumor size increased from 8 mm in 2000 to 25 mm in 2017. The present case is rare in that the carcinoma arose from heterotopic gastric glands. Moreover, the 19-year follow-up revealed that the tumor differentiated to the foveolar epithelium, considered as having high-grade malignancy.
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