Evidence map›Paper›PMID 31165428›Full record

ReviewCerebellum (London, England)2019

Consensus Paper: Experimental Neurostimulation of the Cerebellum.

Lauren N Miterko, Kenneth B Baker, Jaclyn Beckinghausen, Lynley V Bradnam, Michelle Y Cheng, Jessica Cooperrider, Mahlon R DeLong, Simona V Gornati, Mark Hallett, Detlef H Heck and 17 more

Open access · hybridAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Cerebellum (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 8 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 8 syntheses or guidelines pooled it, 158 citations in OpenAlex.

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  12. Cerebellar Transcranial Direct Current Stimulation in Spinocerebellar Ataxia Type 3: a Randomized, Double-Blind, Sham-Controlled Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Trial
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  14. Cerebello-Motor Paired Associative Stimulation and Motor Recovery in Stroke: a Randomized, Sham-Controlled, Double-Blind Pilot Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Trial
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 19 institutions in 8 countries.

Lauren N MiterkoDepartment of Pathology and Immunology, Department of Neuroscience, Program in Developmental Biology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX, 77030, USA.
Kenneth B BakerNeurological Institute, Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Jaclyn BeckinghausenDepartment of Pathology and Immunology, Department of Neuroscience, Program in Developmental Biology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX, 77030, USA.
Lynley V BradnamDepartment of Exercise Science, Faculty of Science, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Michelle Y ChengDepartment of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, MSLS P352, Stanford, CA, 94305-5487, USA.
Jessica CooperriderNeurological Institute, Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Mahlon R DeLongDepartment of Neurology, Emory University, Atlanta, GA, 30322, USA.
Simona V GornatiDepartment of Neuroscience, Erasmus Medical Center, 3015 AA, Rotterdam, Netherlands.
Mark HallettHuman Motor Control Section, NINDS, NIH, Building 10, Room 7D37, 10 Center Dr MSC 1428, Bethesda, MD, 20892-1428, USA.
Detlef H HeckDepartment of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave, Memphis, TN, 38163, USA.
Freek E HoebeekDepartment of Neuroscience, Erasmus Medical Center, 3015 AA, Rotterdam, Netherlands.
Abbas Z KouzaniSchool of Engineering, Deakin University, Geelong, VIC, 3216, Australia.
Sheng-Han KuoDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Elan D LouisDepartment of Neurology, Yale School of Medicine, Department of Chronic Disease Epidemiology, Yale School of Public Health, Center for Neuroepidemiology and Clinical Research, Yale School of Medicine, Yale University, New Haven, CT, 06520, USA.
Andre MachadoNeurological Institute, Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Mario MantoService de Neurologie, CHU-Charleroi, 6000, Charleroi, Belgium.
Alana B McCambridgeGraduate School of Health, Physiotherapy, University of Technology Sydney, PO Box 123, Broadway, Sydney, NSW, 2007, Australia.
Michael A NitscheDepartment of Psychology and Neurosiences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.
Nordeyn Oulad Ben TaibService de Neurochirurgie, CHU Saint-Pierre, 1000, Bruxelles, Belgium.
Traian PopaHuman Motor Control Section, NINDS, NIH, Building 10, Room 7D37, 10 Center Dr MSC 1428, Bethesda, MD, 20892-1428, USA.
Masaki TanakaDepartment of Physiology, Hokkaido University School of Medicine, Sapporo, 060-8638, Japan.
Dagmar TimmannDepartment of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Gary K SteinbergDepartment of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, MSLS P352, Stanford, CA, 94305-5487, USA.
Eric H WangDepartment of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, MSLS P352, Stanford, CA, 94305-5487, USA.
Thomas WichmannDepartment of Neurology, Emory University, Atlanta, GA, 30322, USA.
Tao XieDepartment of Neurology, University of Chicago, 5841 S. Maryland Avenue, MC 2030, Chicago, IL, 60637-1470, USA.
Roy V SillitoeDepartment of Pathology and Immunology, Department of Neuroscience, Program in Developmental Biology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX, 77030, USA. sillitoe@bcm.edu.
Cleveland Clinic · USStanford University · USEmory University · USErasmus MC · NLNational Institutes of Health · USTexas Children's Hospital · USBaylor College of Medicine · USCentre Hospitalier Universitaire de Saint-Pierre · BEColumbia University · USDeakin University · AUGrand Charleroi Hospital · BEHokkaido University · JPTU Dortmund University · DEUniversity of Auckland · NZUniversity of Chicago · USUniversity of Duisburg-Essen · DEUniversity of Technology Sydney · AUUniversity of Tennessee Health Science Center · USYale University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Physiology of Voluntary MovementZIANS002669 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$15.4M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
Identification of Susceptibility Genes for Essential TremorR01NS073872 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLARK, LORRAINE N, LOUIS, ELAN D · 2011 to 2019
$7.4M
Udall Parkinson's Disease Research Center at Emory UniversityP50NS098685 · NINDS · EMORY UNIVERSITY · PI WICHMANN, THOMAS · 2016 to 2020
$6.7M
Environmental Epidemiology of Essential TremorR01NS094607 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2016 to 2020
$3.9M
PATHOLOG-OMICS - ESSENTIAL TREMOR IN THE BROADER CONTEXT OF NEURODEGENERATIONR01NS088257 · NINDS · YALE UNIVERSITY · PI FAUST, PHYLLIS L, LOUIS, ELAN D · 2015 to 2019
$3.3M
in Vivo Quantification of Cerebellar GABA and NAA in Essential TremorR01NS085136 · NINDS · YALE UNIVERSITY · PI MATUSKEY, DAVID A · 2013 to 2017
$3.3M
Deep Brain Stimulation of the Cerebellar Dentate Nucleus to Enhance Chronic, Post-Traumatic Brain Injury RehabilitationR01NS116384 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2020 to 2024
$2.5M
Cerebellar deep brain stimulation to enhance chronic post-stroke rehabilitationR01NS105899 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI BAKER, KENNETH B, MACHADO, ANDRE GUELMAN · 2018 to 2022
$2.5M
Neuronal mechanisms of cerebellar cognitive functionR01MH112143 · NIMH · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HECK, DETLEF H · 2018 to 2022
$2.3M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS U54 HD083092NIH HHS P50-NS098685NIH HHS P51 OD011132NIH HHS R01-NS062876NIMH NIH HHS R01 MH112143NINDS NIH HHS K08 NS083738NINDS NIH HHS P50 NS098685NINDS NIH HHS R01 NS073872NINDS NIH HHS R01 NS085136NINDS NIH HHS R01 NS088257NINDS NIH HHS R01 NS089664NINDS NIH HHS R01NS089664NINDS NIH HHS R01 NS094607NINDS NIH HHS R01 NS100874NINDS NIH HHS R01 NS105899NINDS NIH HHS R01 NS116384
6 · The paper itself

Abstract

The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor behaviors. The contribution of the cerebellum towards different brain functions is underscored by its involvement in a diverse and increasing number of neurological and neuropsychiatric conditions including ataxia, dystonia, essential tremor, Parkinson's disease (PD), epilepsy, stroke, multiple sclerosis, autism spectrum disorders, dyslexia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Although there are no cures for these conditions, cerebellar stimulation is quickly gaining attention for symptomatic alleviation, as cerebellar circuitry has arisen as a promising target for invasive and non-invasive neuromodulation. This consensus paper brings together experts from the fields of neurophysiology, neurology, and neurosurgery to discuss recent efforts in using the cerebellum as a therapeutic intervention. We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.

Indexed as

Models, AnimalAnimalsCerebellumDeep Brain StimulationHumansCerebellumDBSNeuromodulationNeurostimulationNon-invasive therapyOptogenetics

Identifiers

PMID31165428
PMCPMC6867990
OpenAlexW2948144317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.