Evidence map›Paper›PMID 31165386›Full record

ArticleMolecular imaging and biology2020

An Efficient Automated Radiosynthesis and Bioactivity Confirmation of VMAT2 Tracer [

Chao Zhao, Chunyi Liu, Jie Tang, Yingjiao Xu, Minhao Xie, Zhengping Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. A Purification Method ofFrontiers in medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chao ZhaoJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Chunyi LiuKey Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Jie TangKey Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Yingjiao XuKey Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Minhao XieKey Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Zhengping ChenJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China. chenzhengping@jsinm.org.ORCID 0000-0003-1920-9464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to optimize the radiolabeling method of [ PROCEDURES: Optimized labeling conditions were performed by altering the molar ratio of precursor to base (P/B), base species, solvents, reaction temperature, reaction time, and precursor concentration through manual radiosynthesis of [

resultsUnder the optimized conditions (P/K

conclusionsWe obtained an optimized radiolabeling method of [

Indexed as

Fluorine RadioisotopesPositron-Emission TomographyRadiopharmaceuticalsAnimalsCell Line, TumorChromatography, High Pressure LiquidHumansMaleQuality ControlRadiochemistryRatsRats, Sprague-DawleySolventsTetrabenazineVesicular Monoamine Transport ProteinsdihydrotetrabenazineFluorine-18Fluorine RadioisotopesRadiopharmaceuticalsSLC18A2 protein, humanSolventsTetrabenazineVesicular Monoamine Transport Proteins[18F]FP-(+)-DTBZDTBZmicroPETParkinson’s disease (PD)RadiosynthesisVesicular monoamine transporter 2 (VMAT2)

Identifiers

PMID31165386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.