Evidence map›Paper›PMID 31165201›Full record

ReviewCellular and molecular life sciences : CMLS2019

Modulation of miRNA function by natural and synthetic RNA-binding proteins in cancer.

Pascal D Vos, Peter J Leedman, Aleksandra Filipovska, Oliver Rackham

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pascal D VosHarry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, 6009, Australia.ORCID https://orcid.org/0000-0002-5770-8283
Peter J LeedmanHarry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, 6009, Australia.ORCID https://orcid.org/0000-0002-1831-4804
Aleksandra FilipovskaHarry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, 6009, Australia.ORCID https://orcid.org/0000-0002-6998-8403
Oliver RackhamHarry Perkins Institute of Medical Research, QEII Medical Centre, Nedlands, WA, 6009, Australia. oliver.rackham@curtin.edu.au.ORCID http://orcid.org/0000-0002-5301-9624
The University of Western Australia · AUCurtin University · AU

Funding

National Health and Medical Research Council APP1058442
6 · The paper itself

Abstract

RNA-binding proteins (RBPs) and microRNAs (miRNAs) are the most important regulators of mRNA stability and translation in eukaryotic cells; however, the complex interplay between these systems is only now coming to light. RBPs and miRNAs regulate a unique set of targets in either a positive or negative manner and their regulation is mainly opposed to each other on overlapping targets. In some cases, the levels of RBPs or miRNAs regulate the cellular levels of one another and decreased levels of either results in changes in translation of their targets. There is growing evidence that these regulatory circuits are crucial in the development and progression of cancer; however, the rules underlying synergism and antagonism between miRNAs and RNA-binding proteins remain unclear. Synthetic biology seeks to develop artificial systems to better understand their natural counterparts and to develop new, useful technologies for manipulation of gene expression at the RNA level. The recent development of artificial RNA-binding proteins promises to enable a much greater understanding of the importance of the functional interactions between RNA-binding proteins and miRNAs, as well as enabling their manipulation for therapeutic purposes.

Indexed as

Gene Expression Regulation, NeoplasticGenetic Diseases, InbornHumansMicroRNAsNeoplasmsProtein EngineeringRNA-Binding ProteinsRNA Processing, Post-TranscriptionalMicroRNAsRNA-Binding ProteinsDesigner RNA-binding proteinsmiRNAPentatricopeptide repeatPUF domainRNA interferenceRNA–protein interactionsSynthetic biology

Identifiers

PMID31165201
PMCPMC11105495
OpenAlexW2948962706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.