SynthesisAge and ageing2019
Is the association between blood pressure and mortality in older adults different with frailty? A systematic review and meta-analysis.
Synthesis in Age and ageing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Intensive versus standard blood pressure control in older persons with or without diabetes: a systematic review and meta-analysis of randomised controlled trials.Journal of the Royal Society of Medicine · 2023Pooled it
- Identifying older adults with frailty approaching end-of-life: A systematic review.Palliative medicine · 2021Pooled it
- Association between Frailty and Mortality, Falls, and Hospitalization among Patients with Hypertension: A Systematic Review and Meta-Analysis.BioMed research international · 2021Pooled it
- Changes in frailty, intensive blood pressure treatment, and risks of adverse clinical outcomes: a post hoc analysis of the SPRINT trial.BMC medicine · 2025Trial
- Trial
- Efficacy of decentralised home-based antihypertensive treatment in older adults with multimorbidity and polypharmacy (ATEMPT): an open-label randomised controlled pilot trial.The lancet. Healthy longevity · 2024Trial
- Frailty and blood pressure in older adults: rethinking risk and treatment strategies.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Risk of falls and syncope across frailty levels in hypertensive older adults: a longitudinal study.GeroScience · 2026Article
- Consensus statement on practical guidance for optimizing antihypertensive therapy in older adults needing nursing care by the Japan Geriatrics Society and the Japanese Society of Hypertension: English translation of the Japanese article.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Consensus Statement on Practical Guidance for Optimizing Antihypertensive Therapy in Older Adults Needing Nursing Care by the Japan Geriatrics Society and the Japanese Society of Hypertension: English Translation of the Japanese Article.Geriatrics & gerontology international · 2026Article
- Personalizing prevention for healthy cardiovascular aging: Geriatric cardiology in the 2024-2025 hypertension and dyslipidemia guidelines.American journal of preventive cardiology · 2026Article
- Frailty and Cardiovascular Risk.European cardiology · 2026Review
- Baseline and 7-Year longitudinal trajectories of systolic blood pressure and all-cause mortality in the elderly: A large prospective cohort study in China, 2017-2023.AIMS public health · 2025Article
- Deprescribing antihypertensive drugs in frail older adults.Australian prescriber · 2024Review
- Disability level's impact on blood pressure-mortality association in older long-term care adults: evidence from a large Chinese cohort study.BMC geriatrics · 2024Article
- Association between trajectories of systolic blood pressure and frailty outcome in middle-aged and older adults.The journal of nutrition, health & aging · 2024Article
- Review
- Current issues in frailty and hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- [The concept and practical management of frailty in neurology].Revista de neurologia · 2023Review
- Attainment of NICE blood pressure targets among older people with newly diagnosed hypertension: nationwide linked electronic health records cohort study.Age and ageing · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveto investigate whether the association between blood pressure and clinical outcomes is different in older adults with and without frailty, using observational studies.
methodsMEDLINE, EMBASE and CINAHL were searched from 1st January 2000 to 13th June 2018. PROSPERO CRD42017081635. We included all observational studies reporting clinical outcomes in older adults with an average age over 65 years living in the community with and without treatment that measured blood pressure and frailty using validated methods. Two independent reviewers evaluated study quality and risk of bias using the ROBANS tool. We used generic inverse variance modelling to pool risks of all-cause mortality adjusted for age and sex.
resultsnine observational studies involving 21,906 older adults were included, comparing all-cause mortality over a mean of six years. Fixed effects meta-analysis of six studies demonstrated that in people with frailty, there was no mortality difference associated with systolic blood pressure <140 mm Hg compared to systolic blood pressure >140 mm Hg (HR 1.02, 95% CI 0.90 to 1.16). In the absence of frailty, systolic blood pressure <140 mm Hg was associated with lower risk of death compared to systolic blood pressure >140 mm Hg (HR 0.86, 95% CI 0.77 to 0.96).
conclusionsevidence from observational studies demonstrates no mortality difference for older people with frailty whose systolic blood pressure is <140 mm Hg, compared to those with a systolic blood pressure >140 mm Hg. Current evidence fails to capture the complexities of blood pressure measurement, and the association with non-fatal outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.