ArticleEuropean stroke journal2019
Non-cardioembolic stroke/transient ischaemic attack in Asians and non-Asians: A post-hoc analysis of the PERFORM study.
Article in European stroke journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Intensive or standard blood pressure control in patients with a history of ischemic stroke: RESPECT post hoc analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Trial
- Association Between High-Density Lipoprotein Cholesterol Levels and Prognoses in Patients With Stroke.Journal of the American Heart Association · 2026Observational
- Association between Serum Interleukin-6 Levels and Long-term Outcomes after Ischemic Stroke: A Prospective Cohort Study.Journal of atherosclerosis and thrombosis · 2026Observational
- Global expert consensus on the importance of secondary stroke prevention: challenges, care coordination and unmet needs for non-cardioembolic ischaemic stroke survivors.European stroke journal · 2026Article
- Cilostazol plus Aspirin vs. Clopidogrel plus Aspirin in Acute Minor Stroke or Transient Ischemic Attack.Journal of atherosclerosis and thrombosis · 2024Article
- Hyperhomocysteinemia Increases Vascular Risk in Stroke Patients with Chronic Kidney Disease.Journal of atherosclerosis and thrombosis · 2023Observational
- A Nomogram for Predicting the Recurrence of Acute Non-Cardioembolic Ischemic Stroke: A Retrospective Hospital-Based Cohort Analysis.Brain sciences · 2023Article
- Triglyceride-glucose index as a prognostic marker after ischemic stroke or transient ischemic attack: a prospective observational study.Cardiovascular diabetology · 2022Observational
- Characteristics and Prognosis of Stroke in Living Donor Renal Transplant Recipients.Journal of atherosclerosis and thrombosis · 2022Observational
- Blood pressure management for secondary stroke prevention.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Ethnic differences in thromboprophylaxis for COVID-19 patients: should they be considered?International journal of hematology · 2021Review
- The Impact of Cerebral Microbleeds Presence on Outcome Following Minor Stroke Treated With Antiplatelet Therapy.Frontiers in neurology · 2020Article
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Authors and funding
14 authors at 13 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe aimed to compare the characteristics and vascular outcomes between Asian and non-Asian patients with non-cardioembolic stroke/transient ischaemic attack receiving antiplatelet monotherapy and to identify population-specific predictors for recurrent events. PATIENTS AND
methodsWe conducted a post-hoc analysis of data from the PERFORM study, in which 19,100 patients (mean age, 67.2 years; male, 63%; 2178 Asian and 16,922 non-Asian patients) with non-cardioembolic ischaemic stroke/transient ischaemic attack were randomised to aspirin or terutroban and followed for two years. The primary outcome was a composite of major adverse cardiovascular events (non-fatal myocardial infarction, non-fatal stroke and cardiovascular death).
resultsThere was no difference in major adverse cardiovascular events risk between Asian and non-Asian populations (11.1% vs. 10.5%; p = 0.39). However, Asian patients were at significantly higher risk of intracranial haemorrhage (2.4% vs. 1.3%; hazard ratio (HR) 1.87; 95% confidence interval (CI) 1.34-2.60; p < 0.001) and major bleeding (5.4% vs. 4.1%; HR 1.30; 95% CI 1.04-1.61; p = 0.02). Stroke risk was significantly higher in Asian than in non-Asian populations among patients with lacunar stroke (7.4% vs. 4.5%; p = 0.02). In multivariable analysis, diastolic blood pressure (HR per 5 mm Hg 1.08; 95% CI 1.01-1.16; p = 0.03) and diabetes (HR 1.36; 95% CI 1.22-1.52; p < 0.001) were independent predictors of major adverse cardiovascular events for Asian and non-Asian patients, respectively.
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