Evidence map›Paper›PMID 31165051›Full record

ArticleFrontiers in cellular and infection microbiology2019

Development of a Novel

Derald D Charles, James R Fisher, Sarah M Hoskinson, Audrie A Medina-Colorado, Yi C Shen, Mohamad R Chaaban, Steven G Widen, Tonyia D Eaves-Pyles, Carrie A Maxwell, Aaron L Miller and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Frontiers in microbiology · 2026
    Article
  3. Article
  4. Review
  5. [Development of a new platform for testing antiviral drugs using coronavirus-infected human nasal mucosa organoids].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  6. Review
  7. Article
  8. [Establishment of a culture system for human nasal mucosa organoids with controllable differentiation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Derald D CharlesSchool of Medicine, University of Texas Medical Branch, Galveston, TX, United States.
James R FisherSchool of Medicine, University of Texas Medical Branch, Galveston, TX, United States.
Sarah M HoskinsonDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
Audrie A Medina-ColoradoDepartment of Pediatrics, University of Texas Medical Branch, Galveston, TX, United States.
Yi C ShenSchool of Medicine, University of Texas Medical Branch, Galveston, TX, United States.
Mohamad R ChaabanDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, TX, United States.
Steven G WidenDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, United States.
Tonyia D Eaves-PylesDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
Carrie A MaxwellDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States.
Aaron L MillerDepartment of Pediatrics, University of Texas Medical Branch, Galveston, TX, United States.
Vsevolod L PopovDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Richard B PylesSchool of Medicine, University of Texas Medical Branch, Galveston, TX, United States.
The University of Texas Medical Branch at Galveston · US

Funding

Research Resource for Human Organs and Tissues (U42)U42OD011158 · OD · NATIONAL DISEASE RESEARCH INTERCHANGE · PI BELL, THOMAS J · 2012 to 2025
$25.0M
The dynamics of nasal bacterial ecology and S. aureus antagonismR01AI125562 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI PRICE, LANCE BRADLEY · 2016 to 2020
$3.6M
Infectious Diseases and Inflammatory Disorders Training ProgramT35AI078878 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WANG, TIAN · 2008 to 2025
$701k
Modeling Staphylococcus aureus antagonism in pediatric nasal communitiesR21AI123840 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI LIU, CINDY · 2016 to 2017
$447k
NIAID NIH HHS R01 AI125562NIAID NIH HHS R21 AI123840NIAID NIH HHS T35 AI078878NIH HHS U42 OD011158
6 · The paper itself

Abstract

The nasal mucosa provides first line defense against inhaled pathogens while creating a unique microenvironment for bacterial communities. Studying the impact of microbiota in the nasal cavity has been difficult due to limitations with current models including explant cultures, primary cells, or neoplastic cell lines. Most notably, none have been shown to support reproducible colonization by bacterial communities from human donors. Therefore, to conduct controlled studies of the human nasal ecosystem, we have developed a novel

Indexed as

MicrobiotaBacteriaCell LineCells, ImmobilizedCulture TechniquesEcosystemEpithelial CellsFemaleHumansMaleMicrobial InteractionsNasal CavityNasal MucosaTexasVolunteersculture modelhumannasal microbiomenasal mucosarespiratory system

Identifiers

PMID31165051
PMCPMC6536665
OpenAlexW2946360721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.