ArticleBeilstein journal of organic chemistry2019
Electrophilic oligodeoxynucleotide synthesis using dM-Dmoc for amino protection.
Article in Beilstein journal of organic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- PEGylated Dmoc phosphoramidites for sensitive oligodeoxynucleotide synthesis.Organic & biomolecular chemistry · 2023Article
- Oligonucleotide synthesis under mild deprotection conditions.New journal of chemistry = Nouveau journal de chimie · 2023Article
- Effects of Epitranscriptomic RNA Modifications on the Catalytic Activity of the SARS-CoV-2 Replication Complex.Chembiochem : a European journal of chemical biology · 2023Article
- Determination of optical density (OD) of oligodeoxynucleotide from HPLC peak area.PeerJ analytical chemistry · 2022Article
- Dim and Dmoc Protecting Groups for Oligodeoxynucleotide Synthesis.Current protocols in nucleic acid chemistry · 2020Article
- Linear Oligosulfoxides: Synthesis and Solubility Studies.Tetrahedron letters · 2019Article
- Sensitive Oligodeoxynucleotide Synthesis Using Dim and Dmoc as Protecting Groups.The Journal of organic chemistry · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Solid-phase synthesis of electrophilic oligodeoxynucleotides (ODNs) was achieved using dimethyl-Dmoc (dM-Dmoc) as amino protecting group. Due to the high steric hindrance of the 2-(propan-2-ylidene)-1,3-dithiane side product from deprotection, the use of excess nucleophilic scavengers such as aniline to prevent Michael addition of the side product to the deprotected ODN during ODN cleavage and deprotection was no longer needed. The improved technology was demonstrated by the synthesis and characterization of five ODNs including three modified ones. The modified ODNs contained the electrophilic groups ethyl ester, α-chloroamide, and thioester. Using the technology, the sensitive groups can be installed at any location within the ODN sequences without using any sequence- or functionality-specific conditions and procedures.
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Registered trials
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