ReviewWorld journal of emergency surgery : WJES2019
Neutrophil heterogeneity and its role in infectious complications after severe trauma.
Review in World journal of emergency surgery : WJES, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Neutrophil cell surface receptor dynamics following trauma: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player.The journal of trauma and acute care surgery · 2023Trial
- Analysis of human neutrophil phenotypes as biomarker to monitor exercise-induced immune changes.Journal of leukocyte biology · 2021Trial
- The "Double-Edged Sword" of Neutrophils in Trauma: From Pathophysiological Mechanisms to Precision Immunomodulation Strategies.International journal of molecular sciences · 2026Review
- Multimodal single-cell protein and RNA profiling unveils dysregulated immature neutrophil dynamics in gestational diabetes mellitus.Communications biology · 2026Article
- Association of CD16Journal of inflammation research · 2026Article
- Exploratory Study of CD10Scandinavian journal of immunology · 2025Article
- Dysregulation of neutrophil in sepsis: recent insights and advances.Cell communication and signaling : CCS · 2025Review
- Time sequence of bacterial and fungal pathogens causing infections in trauma patients.Trauma surgery & acute care open · 2025Article
- Article
- What trauma patients need: the European dilemma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Review
- New findings on CD16Frontiers in immunology · 2024Observational
- Identification of neutrophil phenotype categories in geriatric hip fracture patients aids in personalized medicine.OTA international : the open access journal of orthopaedic trauma · 2023Article
- Neutrophil nucleus: shaping the past and the future.Journal of leukocyte biology · 2023Article
- Visualization of the inflammatory response to injury by neutrophil phenotype categories : Neutrophil phenotypes after trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Article
- Leucocyte Abnormalities in Synovial Fluid of Degenerative and Inflammatory Arthropathies.International journal of molecular sciences · 2023Article
- Acinetobacter baumannii reinforces the pathogenesis by promoting IL-17 production in a mouse pneumonia model.Medical microbiology and immunology · 2023Article
- Association Between Neutrophil Density and Survival in Trauma Patients Admitted to the Intensive Care Unit; a Retrospective Cohort Study.Archives of academic emergency medicine · 2023Article
- The 'analysis of gene expression and biomarkers for point-of-care decision support in Sepsis' study; temporal clinical parameter analysis and validation of early diagnostic biomarker signatures for severe inflammation andsepsis-SIRS discrimination.Frontiers in immunology · 2023Article
- Perioperative arginine prevents metastases by accelerating natural killer cell recovery after surgery.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Trauma leads to a complex inflammatory cascade that induces both immune activation and a refractory immune state in parallel. Although both components are deemed necessary for recovery, the balance is tight and easily lost. Losing the balance can lead to life-threatening infectious complications as well as long-term immunosuppression with recurrent infections. Neutrophils are known to play a key role in these processes. Therefore, this review focuses on neutrophil characteristics and function after trauma and how these features can be used to identify trauma patients at risk for infectious complications. Results: Distinct neutrophil subtypes exist that play their own role in the recovery and/or development of infectious complications after trauma. Furthermore, the refractory immune state is related to the risk of infectious complications. These findings change the initial concepts of the immune response after trauma and give rise to new biomarkers for monitoring and predicting inflammatory complications in severely injured patients. Conclusion: For early recognition of patients at risk, the immune system should be monitored. Several neutrophil biomarkers show promising results and analysis of these markers has become accessible to such extent that they can be used for point-of-care decision making after trauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.