Evidence map›Paper›PMID 31164905›Full record

ArticleFrontiers in genetics2019

Gene Expression Noise Produces Cell-to-Cell Heterogeneity in Eukaryotic Homologous Recombination Rate.

Jian Liu, Jean-Marie François, Jean-Pascal Capp

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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  12. Characterization of systemic genomic instability in budding yeast.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. G3 (Bethesda, Md.) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jian LiuLaboratoire d'Ingénierie des Systèmes Biologiques et des Procédés, Institut National des Sciences Appliquées de Toulouse, UMR CNRS 5504, UMR INRA 792, Université de Toulouse, Toulouse, France.
Jean-Marie FrançoisLaboratoire d'Ingénierie des Systèmes Biologiques et des Procédés, Institut National des Sciences Appliquées de Toulouse, UMR CNRS 5504, UMR INRA 792, Université de Toulouse, Toulouse, France.
Jean-Pascal CappLaboratoire d'Ingénierie des Systèmes Biologiques et des Procédés, Institut National des Sciences Appliquées de Toulouse, UMR CNRS 5504, UMR INRA 792, Université de Toulouse, Toulouse, France.
Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Variation in gene expression among genetically identical individual cells (called gene expression noise) directly contributes to phenotypic diversity. Whether such variation can impact genome stability and lead to variation in genotype remains poorly explored. We addressed this question by investigating whether noise in the expression of genes affecting homologous recombination (HR) activity either directly (

Indexed as

rate of evolutionrecombinationSaccharomyces cerevisiaesingle-cell analysisstochastic gene expressionyeast

Identifiers

PMID31164905
PMCPMC6536703
OpenAlexW2917248584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.