ArticleFrontiers in physiology2019
Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of isolated, confined and extreme environments on parameters of the immune system - a systematic review.Frontiers in immunology · 2025Pooled it
- Human social isolation and stress: a systematic review of different contexts and recommendations for future studies.Trends in psychiatry and psychotherapy · 2024Pooled it
- Exploring plant responses to altered gravity for advancing space agriculture.Plant communications · 2025Review
- Space exploration and lifestyle medicine: a narrative review of its implications for astronaut health and remote Earth-based environments.Frontiers in physiology · 2025Review
- Carotid wall structure during and after 6 months of spaceflight.Frontiers in physiology · 2025Article
- Human and space ethology as a methodology-based solution for interdisciplinary research.Frontiers in physiology · 2025Article
- Exercise combined with artificial gravity and exercise only countermeasures prevent organ and blood vessel morpholgical changes induced by 55 days HDT bedrest.Frontiers in physiology · 2024Article
- Ultrasound assessments of organs and blood vessels before and after 40 days isolation in a cavern (deep time experiment 2021).Frontiers in physiology · 2023Article
- Integrating bioinformatic strategies in spatial life science research.Briefings in bioinformatics · 2022Review
- Review
- How Experiences Affect Psychological Responses During Supervised Fasting: A Preliminary Study.Frontiers in psychology · 2021Article
- COVID-19-The largest isolation study in history: the value of shared learnings from spaceflight analogs.NPJ microgravity · 2020Review
- Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures.Frontiers in physiology · 2020Review
- Current Progression: Application of High-Throughput Sequencing Technique in Space Microbiology.BioMed research international · 2020Review
- Temporal Characteristics of the Oropharyngeal and Nasal Microbiota Structure in Crewmembers Stayed 180 Days in the Controlled Ecological Life Support System.Frontiers in microbiology · 2020Article
- Physiological Acclimatization of the Liver to 180-Day Isolation and the Mars Solar Day.BioMed research international · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Confinement experiments are essential to prepare long-term space exploration. The 180-day Chinese CELSS (Controlled Ecological Life Support System) study is unique in its design, including a closed-loop system and mid-mission simulation of Mars-like day-night cycle of 24 h 40 min for 36 days (days 72-108). Our aim was to study physiological and psychological consequences of this confinement in four healthy volunteers (one female). CELSS platform consisted of six interconnected modules including four greenhouses. Life support systems were controlled automatically. Body composition, fluid compartments, metabolic state, heart, large vessels, endothelial function, and muscle tone were studied using biological, functional, and/or morphological measurements. Behavioral activities were studied by ethological monitoring; psychological state was assessed by questionnaires. Body weight decreased by ∼2 kg mostly due to lean mass loss. Plasma volume and volume-regulating hormones were mostly stable. Carotid intima-media thickness (IMT) increased by 10-15%. Endothelium-dependent vasodilation decreased. Masseter tone increased by 6-14% suggesting stress, whereas paravertebral muscle tone diminished by 10 ± 6%. Behavioral flow reflecting global activity decreased 1.5- to 2-fold after the first month. Psychological questionnaires revealed decrease in hostility and negative emotions but increase in emotional adaptation suggesting boredom and monotony. One subject was clearly different with lower fitness, higher levels of stress and anxiety, and somatic signs as back pain, peak in masseter tone, increased blood cortisol and C-reactive protein. Comparison of CELSS experiment with Mars500 confinement program suggests the need for countermeasures to prevent increased IMT and endothelial deconditioning. Daily activity in greenhouse could act as countermeasure against psycho-physiological deconditioning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.