Evidence map›Paper›PMID 31164800›Full record

ArticleFrontiers in neuroscience2019

Laetitia Chauvière, Frederick Pothof, Kai S Gansel, Johanna Klon-Lipok, Arno A A Aarts, Tobias Holzhammer, Oliver Paul, Wolf J Singer, Patrick Ruther

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
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  8. Review
  9. Article
  10. Neural microprobe modelling and microfabrication for improved implantation and mechanical failure mitigation.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laetitia ChauvièreMax Planck Institute for Brain Research, Frankfurt am Main, Germany.
Frederick PothofDepartment of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg im Breisgau, Germany.
Kai S GanselMax Planck Institute for Brain Research, Frankfurt am Main, Germany.
Johanna Klon-LipokMax Planck Institute for Brain Research, Frankfurt am Main, Germany.
Arno A A AartsATLAS Neuroengineering bvba, Leuven, Belgium.
Tobias HolzhammerATLAS Neuroengineering bvba, Leuven, Belgium.
Oliver PaulDepartment of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg im Breisgau, Germany.
Wolf J SingerMax Planck Institute for Brain Research, Frankfurt am Main, Germany.
Patrick RutherDepartment of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg im Breisgau, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Throughout the past decade, silicon-based neural probes have become a driving force in neural engineering. Such probes comprise sophisticated, integrated CMOS electronics which provide a large number of recording sites along slender probe shanks. Using such neural probes in a chronic setting often requires them to be mechanically anchored with respect to the skull. However, any relative motion between brain and implant causes recording instabilities and tissue responses such as glial scarring, thereby shielding recordable neurons from the recording sites integrated on the probe and thus decreasing the signal quality. In the current work, we present a comparison of results obtained using mechanically fixed and floating silicon neural probes chronically implanted into the cortex of a non-human primate. We demonstrate that the neural signal quality estimated by the quality of the spiking and local field potential (LFP) recordings over time is initially superior for the floating probe compared to the fixed device. Nonetheless, the skull-fixed probe also allowed long-term recording of multi-unit activity (MUA) and low frequency signals over several months, especially once pulsations of the brain were properly controlled.

Indexed as

fixed probesfloating probesin vivo recordingnon-human primatessilicon-based neural probesvisual cortex

Identifiers

PMID31164800
PMCPMC6536660

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.