ReviewEye (London, England)2019
Cellular imaging of inherited retinal diseases using adaptive optics.
Review in Eye (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Adaptive Optics Image Analysis Using Generative AI (GPT-4) Scripting: Exploratory Study.JMIR formative research · 2026Article
- Validation of a Rule-Based Automated Method for RPE Cell Detection Using Adaptive Optics Transscleral Flood Illumination.Translational vision science & technology · 2026Article
- In-Vivo Characterization of Healthy Retinal Pigment Epithelium and Photoreceptor Cells from AO-(T)FI Imaging.Vision (Basel, Switzerland) · 2025Article
- From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases.Diagnostics (Basel, Switzerland) · 2024Review
- Ultrafast adaptive optics for imaging the living human eye.Nature communications · 2024Article
- Adaptive optics retinal imaging in patients with usher syndrome.Frontiers in ophthalmology · 2024Article
- Clinical Application of Adaptive Optics Imaging in Diagnosis, Management, and Monitoring of Ophthalmological Diseases: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Progression of Rare Inherited Retinal Dystrophies May Be Monitored by Adaptive Optics Imaging.Life (Basel, Switzerland) · 2023Article
- Characteristics of Rare Inherited Retinal Dystrophies in Adaptive Optics-A Study on 53 Eyes.Diagnostics (Basel, Switzerland) · 2023Article
- A versatile laser-induced porcine model of outer retinal and choroidal degeneration for preclinical testing.JCI insight · 2023Article
- Comprehensive automatic processing and analysis of adaptive optics flood illumination retinal images on healthy subjects.Biomedical optics express · 2023Article
- Deep learning-enabled volumetric cone photoreceptor segmentation in adaptive optics optical coherence tomography images of normal and diseased eyes.Biomedical optics express · 2023Article
- Investigating Biomarkers forInternational journal of molecular sciences · 2022Article
- Photoreceptor degeneration in ABCA4-associated retinopathy and its genetic correlates.JCI insight · 2022Observational
- Gene-Based Therapeutics for Inherited Retinal Diseases.Frontiers in genetics · 2021Review
- Adaptive optics for high-resolution imaging.Nature reviews. Methods primers · 2021Article
- Is subretinal AAV gene replacement still the only viable treatment option for choroideremia?Expert opinion on orphan drugs · 2021Article
- Cellular-Scale Imaging of Transparent Retinal Structures and Processes Using Adaptive Optics Optical Coherence Tomography.Annual review of vision science · 2020Review
- Novel Heterozygous Deletion in Retinol Dehydrogenase 12 (Frontiers in genetics · 2020Article
- The role of multimodal imaging and vision function testing inTherapeutic advances in ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Adaptive optics (AO) is an insightful tool that has been increasingly applied to existing imaging systems for viewing the retina at a cellular level. By correcting for individual optical aberrations, AO offers an improvement in transverse resolution from 10-15 μm to ~2 μm, enabling assessment of individual retinal cell types. One of the settings in which its utility has been recognised is that of the inherited retinal diseases (IRDs), the genetic and clinical heterogeneity of which warrants better cellular characterisation. In this review, we provide a summary of the basic principles of AO, its integration into multiple retinal imaging modalities and its clinical applications, focusing primarily on IRDs. Furthermore, we present a comprehensive summary of AO-based cellular findings in IRDs according to their associated disease-causing genes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.