ArticleNature communications2019
CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
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57 citing papers in PubMed, 105 citations in OpenAlex.
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- Mechanoresponsive reprogramming of tumor-associated macrophages during cancer progression.Frontiers in cell and developmental biology · 2026Review
- TMB as a predictive biomarker for ICI response in TNBC: current evidence and future directions for augmented anti-tumor responses.Clinical and experimental medicine · 2025Review
- CAMKKβ supports growth and viability of epithelial ovarian cancer in vitro and in vivo.Scientific reports · 2025Article
- CaMKK2 as a therapeutic target to combat metastasis in glioblastoma.Molecular biology reports · 2025Review
- CaMKK2 Regulates Macrophage Polarization Induced by Matrix Stiffness: Implications for Shaping the Immune Response in Stiffened Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Delineation of signaling routes that underlie differences in macrophage phenotypic states.NAR molecular medicine · 2025Article
- GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth.Journal for immunotherapy of cancer · 2024Article
- Gasdermin D Mediated Mitochondrial Metabolism Orchestrate Neurogenesis Through LDHA During Embryonic Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Development of NR0B2 as a therapeutic target for the re-education of tumor associated myeloid cells.Cancer letters · 2024Article
- Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review).Experimental and therapeutic medicine · 2024Review
- Kinase signalling adaptation supports dysfunctional mitochondria in disease.Frontiers in molecular biosciences · 2024Review
- The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy.Genes & diseases · 2024Review
- Crosstalk Between Macrophages and Breast Cancer Cells: Networking Within Tumors.Results and problems in cell differentiation · 2024Review
- The cellular composition of the tumor microenvironment is an important marker for predicting therapeutic efficacy in breast cancer.Frontiers in immunology · 2024Review
- Kinetic Detection of Apoptosis Events Via Caspase 3/7 Activation in a Tumor-Immune Microenvironment on a Chip.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Psilocybin and Eugenol Reduce Inflammation in Human 3D EpiIntestinal Tissue.Life (Basel, Switzerland) · 2023Article
- The elusive Luminal B breast cancer and the mysterious chemokines.Journal of cancer research and clinical oncology · 2023Article
Corrections and comments
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Authors and funding
22 authors at 7 institutions in 2 countries.
Luigi RacioppiDepartment of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC, 27710, USA. luigi.racioppi@duke.edu.ORCID http://orcid.org/0000-0002-9207-6752
Erik R NelsonMolecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.ORCID http://orcid.org/0000-0002-8887-1905
Wei HuangDepartment of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC, 27710, USA.
Debarati MukherjeeDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
Scott A LawrenceDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
William LentoDepartment of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC, 27710, USA.
Anna Maria MasciDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC, 27710, USA.ORCID http://orcid.org/0000-0003-1940-6740
Yiquin JiaoDepartment of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC, 27710, USA.
Sunghee ParkDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
Brian YorkDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Yaping LiuDepartment of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC, 27710, USA.
Amy E BaekMolecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
David H DrewryDepartment of Chemical Biology, GlaxoSmithKline, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0000-0001-5973-5798
William J ZuercherDepartment of Chemical Biology, GlaxoSmithKline, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0000-0002-9836-0068
Francesca R BertaniCNR IFN Institute for Photonics and Nanotechnologies, Rome, 00156, Italy.ORCID http://orcid.org/0000-0001-6529-8993
Luca BusinaroCNR IFN Institute for Photonics and Nanotechnologies, Rome, 00156, Italy.ORCID http://orcid.org/0000-0002-5251-093X
Joseph GeradtsDepartment of Population Sciences, City of Hope National Medical Center, Duarte, CA, 91010, USA.
Allison HallDepartment of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.
Anthony R MeansDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Nelson ChaoDepartment of Medicine, Division of Hematological Malignancies and Cellular Therapy, Duke University School of Medicine, Durham, NC, 27710, USA.
Ching-Yi ChangDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID http://orcid.org/0000-0003-2115-9574
Donald P McDonnellDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA. Donald.McDonnell@duke.edu.ORCID http://orcid.org/0000-0002-7331-4700
Duke University · USBaylor College of Medicine · USCenter for Biomolecular Nanotechnologies · ITUniversity of Illinois Urbana-Champaign · USUniversity of North Carolina at Chapel Hill · USCity Of Hope National Medical Center · USEli Lilly (United States) · US
Funding
The role of ERRalpha/PGC-1 in disease pathogenesisR01CA174643 · NCI · DUKE UNIVERSITY · PI MCDONNELL, DONALD P · 2013 to 2017
$1.6M27-hydroxycholesterol as a link between obesity and breast cancer pathogenesisR00CA172357 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NELSON, ERIK RUSSELL · 2014 to 2016
$727kData commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598kNCI NIH HHS R00 CA172357NCI NIH HHS R01 CA174643NIH HHS S10 OD018164
Abstract
Tumor-associated myeloid cells regulate tumor growth and metastasis, and their accumulation is a negative prognostic factor for breast cancer. Here we find calcium/calmodulin-dependent kinase kinase (CaMKK2) to be highly expressed within intratumoral myeloid cells in mouse models of breast cancer, and demonstrate that its inhibition within myeloid cells suppresses tumor growth by increasing intratumoral accumulation of effector CD8
Indexed as
AnimalsBreast NeoplasmsCalcium-Calmodulin-Dependent Protein Kinase KinaseCarcinomaCD8-Positive T-LymphocytesCell ProliferationChemokinesFemaleHumansImmunohistochemistryIn Vitro TechniquesMacrophagesMammary Neoplasms, AnimalMiceMice, KnockoutMice, TransgenicCalcium-Calmodulin-Dependent Protein Kinase KinaseCAMKK2 protein, humanCamkk2 protein, mouseChemokines
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