Evidence map›Paper›PMID 31164641›Full record

ArticleNature communications2019

Aβ-induced vulnerability propagates via the brain's default mode network.

Tharick A Pascoal, Sulantha Mathotaarachchi, Min Su Kang, Sara Mohaddes, Monica Shin, Ah Yeon Park, Maxime J Parent, Andrea L Benedet, Mira Chamoun, Joseph Therriault and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 90 citations in OpenAlex.

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  13. Functional connectome through the human life span.bioRxiv : the preprint server for biology · 2024
    Article
  14. Review
  15. Tau accumulation and atrophy predict amyloid independent cognitive decline in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Tharick A PascoalTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.ORCID http://orcid.org/0000-0001-9057-8014
Sulantha MathotaarachchiTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.
Min Su KangTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.
Sara MohaddesTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.
Monica ShinTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.
Ah Yeon ParkStatistical Laboratory, University of Cambridge, CB3 0WB, Cambridge, UK.
Maxime J ParentTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.
Andrea L BenedetTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.ORCID http://orcid.org/0000-0001-8219-1741
Mira ChamounTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.
Joseph TherriaultTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.
Heungsun HwangDepartment of Psychology, McGill University, Montreal, Canada.
A Claudio CuelloDepartment of Pharmacology and Therapeutics, McGill University, H3A 2T5, Montreal, Canada.
Bratislav MisicMontreal Neurological Institute, H3A 2B4, Montreal, Canada.
Jean-Paul SoucyMontreal Neurological Institute, H3A 2B4, Montreal, Canada.
John A D AstonStatistical Laboratory, University of Cambridge, CB3 0WB, Cambridge, UK.
Serge GauthierAlzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, H4H 1R3, Montreal, Canada. pedro.rosa@mcgill.ca.ORCID http://orcid.org/0000-0001-9116-1376
McGill University · CAMontreal Neurological Institute and Hospital · CAMcGill University Health Centre · CAUniversity of Cambridge · GB

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer's disease. Here, using positron emission tomography ([

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsAnimalsAnimals, Genetically ModifiedBrainCognitive DysfunctionEthylene GlycolsFluorodeoxyglucose F18HumansMagnetic Resonance ImagingNeural PathwaysNeurofibrillary TanglesPositron-Emission TomographyRadiopharmaceuticalsRatsAmyloid beta-PeptidesAniline CompoundsEthylene GlycolsflorbetapirFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID31164641
PMCPMC6547716
OpenAlexW2948296075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.