ArticleCell death & disease2019
c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- C-Kit Is Essential for Vascular Smooth Muscle Cell Phenotypic Switch In Vitro and In Vivo After Injury.Cells · 2025Article
- Heart-derived endogenous stem cells.Molecular biology reports · 2025Review
- Echocardiographic Assessment of Cardiac Function in Mouse Models of Heart Disease.International journal of molecular sciences · 2025Review
- Proteomic analysis of neonatal mouse hearts shows PKA functions as a cardiomyocyte replication regulator.Proteome science · 2023Article
- Article
- Polarizing Macrophage Functional Phenotype to Foster Cardiac Regeneration.International journal of molecular sciences · 2023Review
- A Mouse Model of Dilated Cardiomyopathy Produced by Isoproterenol Acute Exposure Followed by 5-Fluorouracil Administration.Journal of cardiovascular development and disease · 2023Article
- Endothelial Glycocalyx and Cardiomyocyte Damage Is Prevented by Recombinant Syndecan-1 in Acute Myocardial Infarction.The American journal of pathology · 2023Article
- Metabolic Changes in Cardiac Aging.Reviews in cardiovascular medicine · 2023Review
- Streptozotocin-Induced Type 1 and 2 Diabetes Mellitus Mouse Models Show Different Functional, Cellular and Molecular Patterns of Diabetic Cardiomyopathy.International journal of molecular sciences · 2023Article
- The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation.Clinical science (London, England : 1979) · 2022Review
- The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues.International journal of molecular sciences · 2022Review
- Myocardial regeneration protocols towards the routine clinical scenario: An unseemly path from bench to bedside.EClinicalMedicine · 2022Review
- 'Youthful' phenotype of c-KitCellular and molecular life sciences : CMLS · 2022Article
- Atypically Shaped Cardiomyocytes (ACMs): The Identification, Characterization and New Insights into a Subpopulation of Cardiomyocytes.Biomolecules · 2022Review
- Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells.Scientific reports · 2022Article
- Article
- Article
- The impact of autophagy modulation on phenotype and survival of cardiac stromal cells under metabolic stress.Cell death discovery · 2022Article
- Lyotropic Liquid Crystals: A Biocompatible and Safe Material for Local Cardiac Application.Pharmaceutics · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 5 institutions in 2 countries.
Iolanda AquilaMolecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, 88100, Italy.
Eleonora CianfloneMolecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, 88100, Italy.
Mariangela ScaliseMolecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, 88100, Italy.
Fabiola MarinoMolecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, 88100, Italy.
Teresa MancusoMolecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, 88100, Italy.
Andrea FilardoMolecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, 88100, Italy.
Andrew J SmithMolecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, 88100, Italy.ORCID http://orcid.org/0000-0001-7283-5611
Donato CappettaSection of Pharmacology, Department of Experimental Medicine, University of Campania "L.Vanvitelli", Naples, 80121, Italy.
Antonella De AngelisSection of Pharmacology, Department of Experimental Medicine, University of Campania "L.Vanvitelli", Naples, 80121, Italy.
Konrad UrbanekSection of Pharmacology, Department of Experimental Medicine, University of Campania "L.Vanvitelli", Naples, 80121, Italy.
Andrea M IsidoriDepartment of Experimental Medicine, "La Sapienza" University, Rome, 00161, Italy.
Michele TorellaDepartment of Cardiothoracic Surgery, University of Campania "L.Vanvitelli", Naples, 80121, Italy.
Valter AgostiInterdepartmental Center of Services (CIS) and Department of Experimental and Clinical Medicine, University Magna Graecia, Campus Salvatore Venuta-Viale Europa, Catanzaro, 88100, Italy.ORCID http://orcid.org/0000-0001-6785-093X
Giuseppe VigliettoInterdepartmental Center of Services (CIS) and Department of Experimental and Clinical Medicine, University Magna Graecia, Campus Salvatore Venuta-Viale Europa, Catanzaro, 88100, Italy.
Bernardo Nadal-GinardMolecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, 88100, Italy. bernardo.nadalginard@gmail.com.
Georgina M Ellison-HughesFaculty of Life Sciences, School of Basic and Medical Biosciences, King's College London, Guy's Campus, London, SE1 1UL, UK.ORCID http://orcid.org/0000-0002-2733-3361
Daniele TorellaMolecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, 88100, Italy. dtorella@unicz.it.ORCID http://orcid.org/0000-0002-4915-5084
Magna Graecia University · ITUniversity of Campania "Luigi Vanvitelli" · ITKing's College London · GBSapienza University of Rome · ITUniversity of Leeds · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
An overdose of Isoproterenol (ISO) causes acute cardiomyocyte (CM) dropout and activates the resident cardiac c-kit
Indexed as
Adult Stem CellsAnimalsApoptosisCell DifferentiationCell ProliferationCells, CulturedHaploinsufficiencyHeart VentriclesIsoproterenolMaleMiceMice, Inbred C57BLMice, KnockoutMuscle DevelopmentMyocytes, CardiacNecrosisIsoproterenolProto-Oncogene Proteins c-kit
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.