ArticlemBio2019
Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus.
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In one paragraph
Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 64 citations in OpenAlex.
- The putative mitochondrial serine protease Pim1 regulates azole tolerance through redox homeostasis in Aspergillus fumigatus.Archives of microbiology · 2026Article
- Antifungal resistance: from classical mechanisms to the expanding role of acetyltransferases.Journal of biomedical science · 2026Review
- Multicenter evaluation of low inoculum and a colorimetric assay for antifungal susceptibility testing ofJournal of clinical microbiology · 2026Article
- Echinocandins have an alternative mode of action on biomimetic membranes that is not directly related to the functioning of (1,3) beta-glucan synthase.Cell death discovery · 2026Article
- Molecular landscape of the fungal plasma membrane and implications for antifungal action.Nature communications · 2025Article
- Repositioning Antimicrobial Peptides Against WHO-Priority Fungi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Agricultural SDHIs Induce Azole Resistance in Aspergillus fumigatus via Mitochondrial Sdh1 Suppression.Mycopathologia · 2025Article
- FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance.Nature microbiology · 2025Article
- Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata.Nature communications · 2025Article
- Aspergillus fumigatus escape mechanisms from its harsh survival environments.Applied microbiology and biotechnology · 2024Review
- The Influence ofJournal of fungi (Basel, Switzerland) · 2024Article
- Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis.PLoS pathogens · 2024Article
- Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β-1,3-glucan synthesis inhibition.Nature communications · 2024Article
- Commercial Methods for Antifungal Susceptibility Testing of Saprophytic Molds: Can They Be Used to Detect Resistance?Journal of fungi (Basel, Switzerland) · 2024Review
- Editorial: Mitochondrial function and dysfunction in pathogenic fungi.Frontiers in physiology · 2024Article
- Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action.Antibiotics (Basel, Switzerland) · 2023Review
- The rapid emergence of antifungal-resistant human-pathogenic fungi.Nature reviews. Microbiology · 2023Review
- Optimization of the EUCAST reference broth microdilution method for echinocandin susceptibility testing of Aspergillus fumigatus.The Journal of antimicrobial chemotherapy · 2023Article
- Surveillance of Amphotericin B and Azole Resistance inJournal of fungi (Basel, Switzerland) · 2023Article
- Drug-ResistantPathogens (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Shruthi SatishCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Cristina Jiménez-OrtigosaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Yanan ZhaoCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Min Hee LeeCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Enriko DolgovCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Thomas KrügerLeibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Steven ParkCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
David W DenningNational Aspergillosis Centre, Wythenshawe Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Olaf KniemeyerLeibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.ORCID 0000-0002-9493-6402
Axel A BrakhageLeibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
David S PerlinCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA David.Perlin@hmh-cdi.org.
Hackensack Meridian Health · USLeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEManchester Academic Health Science Centre · GBRutgers, The State University of New Jersey · US
Funding
Critical Factors Influencing Echinocandin Resistance in CandidaglabrataR01AI109025 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PERLIN, DAVID S · 2014 to 2025
$9.8MNIAID NIH HHS R01 AI109025
Abstract
PubMed holds no abstract for this paper.
Indexed as
Stress, PhysiologicalAntifungal AgentsAspergillosisAspergillus fumigatusDrug Resistance, FungalEchinocandinsFungal ProteinsGlucosyltransferasesHumansMicrobial Sensitivity TestsOxidative StressProtein Processing, Post-TranslationalReactive Oxygen SpeciesSphingosine1,3-beta-glucan synthaseAntifungal AgentsEchinocandinsFungal ProteinsGlucosyltransferasesphytosphingosineReactive Oxygen SpeciessafingolSphingosineantifungal resistanceAspergillus fumigatuscaspofunginechinocandinsglucan synthaseglucan synthase inhibitorslipidsROS
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.