ArticleThe European respiratory journal2019
Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids.
Article in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
- Metabolomics-Based Analysis Linking Oxidative Stress-Related Branched-Chain Amino Acid (BCAA) Pathway with Atopic Indices to Childhood Allergies.Antioxidants (Basel, Switzerland) · 2026Article
- Early life group 2 innate lymphoid cells in health and disease.Molecular and cellular pediatrics · 2026Review
- Asthma Phenotype Progression in Children and Adolescents: A Single Center Experience.Pediatric pulmonology · 2025Article
- The role of mesenchymal stem cell‑derived exosomes in asthma (Review).Molecular medicine reports · 2025Review
- Basic implications on three pathways associated with SARS-CoV-2.Biomedical journal · 2025Review
- CD11b Expression Level Measurement to Distinguish Asthma Phenotype in Pediatric Patients.Avicenna journal of medicine · 2025Article
- Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma.The Journal of clinical investigation · 2024Article
- Natural killer cells and innate lymphoid cells but not NKT cells are mature in their cytokine production at birth.Clinical and experimental immunology · 2024Article
- JAK3 inhibitor suppresses multipotent ILC2s and attenuates steroid-resistant asthma.Science advances · 2023Article
- The modulation of pulmonary group 2 innate lymphoid cell function in asthma: from inflammatory mediators to environmental and metabolic factors.Experimental & molecular medicine · 2023Review
- Childhood asthma phenotypes and endotypes: a glance into the mosaic.Molecular and cellular pediatrics · 2023Review
- Treatment mechanism of immune triad from the repurposing drug against COVID-19.Translational medicine of aging · 2023Review
- Emerging Insights into the Impact of Air Pollution on Immune-Mediated Asthma Pathogenesis.Current allergy and asthma reports · 2022Review
- Severe asthma in children: An official statement from Saudi Pediatric Pulmonology Association.Saudi medical journal · 2022Article
- Memory-like innate lymphoid cells in the pathogenesis of asthma.Frontiers in immunology · 2022Review
- Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma.Annual review of immunology · 2021Article
- High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status.Cell reports · 2021Article
- The impact of obesity on immune function in pediatric asthma.Current opinion in allergy and clinical immunology · 2021Review
- Therapeutic manipulation of innate lymphoid cells.JCI insight · 2021Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Children with severe therapy-resistant asthma (STRA) have poor control despite maximal treatment, while those with difficult asthma (DA) have poor control from failure to implement basic management, including adherence to therapy. Although recognised as clinically distinct, the airway molecular phenotype, including the role of innate lymphoid cells (ILCs) and their response to steroids in DA and STRA is unknown.Immunophenotyping of sputum and blood ILCs and T-cells from STRA, DA and non-asthmatic controls was undertaken. Leukocytes were analysed longitudinally pre- and post-intramuscular triamcinolone in children with STRA. Cultured ILCs were evaluated to assess steroid responsiveness
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.