Evidence map›Paper›PMID 31164433›Full record

ArticleThe European respiratory journal2019

Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD.

Jane F Chisholm, Siddharth K Shenoy, Julie K Shade, Victor Kim, Nirupama Putcha, Kathryn A Carson, Robert Wise, Nadia N Hansel, Justin S Hanes, Jung Soo Suk and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Nanotechnology-Based Therapeutics for Airway Inflammatory Diseases.Clinical reviews in allergy & immunology · 2025
    Review
  6. Review
  7. Review
  8. Advances in nanomaterial-based targeted drug delivery systems.Frontiers in bioengineering and biotechnology · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Reliably sourced airway mucus.American journal of physiology. Lung cellular and molecular physiology · 2019
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jane F ChisholmCenter for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Siddharth K ShenoyCenter for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Julie K ShadeCenter for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Victor KimDept of Thoracic Medicine and Surgery, Temple University School of Medicine, Philadelphia, PA, USA.
Nirupama PutchaDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kathryn A CarsonDept of Epidemiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-1548-6918
Robert WiseDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8353-2349
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Justin S HanesCenter for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jung Soo SukCenter for Nanomedicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Enid NeptuneDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA eneptune@jhmi.edu jsuk@jhmi.edu hanes@jhmi.edu.
Johns Hopkins University · USTemple University · US

Funding

Mucus Microstructure and Osmotic Pressure: Biomarkers for CB in COPDR01HL125169 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NEPTUNE, ENID R, SUK, JUNG SOO · 2015 to 2018
$1.7M
Biodegradable Mucus Penetrating DNA Nanoparticle for Gene Therapy of CFR01HL127413 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HANES, JUSTIN S., SUK, JUNG SOO · 2015 to 2018
$1.6M
Th17 inflammation is responsible for mucous metaplasia in COPDK23HL094696 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KIM, VICTOR · 2011 to 2014
$563k
NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K23 HL094696NHLBI NIH HHS R01 HL125169NHLBI NIH HHS R01 HL127413
6 · The paper itself

Abstract

Perturbations in airway mucus properties contribute to lung function decline in patients with chronic obstructive pulmonary disease (COPD). While alterations in bulk mucus rheology have been widely explored, microscopic mucus properties that directly impact on the dynamics of microorganisms and immune cells in the COPD lungs are yet to be investigated.We hypothesised that a tightened mesh structure of spontaneously expectorated mucus (

Indexed as

SputumDiffusionFemaleForced Expiratory VolumeHumansMaleMiddle AgedNanoparticlesPulmonary Disease, Chronic ObstructiveRespiratory Function TestsRheologyRisk FactorsSmokingSpirometry

Identifiers

PMID31164433
PMCPMC8081045
OpenAlexW2948384221

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.