ArticleProceedings of the National Academy of Sciences of the United States of America2019
Boundary mode lubrication of articular cartilage with a biomimetic diblock copolymer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07611708 (First in Human Safety Evaluation of a Novel Polymer for Knee Osteoarthritis), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
First in Human Safety Evaluation of a Novel Polymer for Knee Osteoarthritis
Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Trojan horse-inspired vaccine-like nanoparticle with enhanced lubrication and active-passive synergistic anti-inflammation for post-traumatic osteoarthritis treatment.Bioactive materials · 2027Article
- Proteoglycan-Mimetic Bottle-Brush Polymer Brushes for Osteoarthritis Therapy: Lubrication Enhancement and Multifunctional Disease Modulation.Macromolecular rapid communications · 2026Review
- Lubricin in osteoarthritis: functions and therapeutic prospects.Frontiers in immunology · 2026Review
- O-glycans Expand Lubricin and Attenuate Its Viscosity and Shear Thinning.Biomacromolecules · 2024Article
- Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy.Nature reviews. Rheumatology · 2024Review
- Lubricating Polymer Gels/Coatings: Syntheses and Measurement Strategies.Gels (Basel, Switzerland) · 2024Review
- Brushing Up on Cartilage Lubrication: Polyelectrolyte-Enhanced Tribological Rehydration.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Spatial Lipidomic Profiling of Mouse Joint Tissue Demonstrates the Essential Role of PHOSPHO1 in Growth Plate Homeostasis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives.Bioactive materials · 2023Review
- Review
- A Tribological Comparison of Facet Joint, Sacroiliac Joint, and Knee Cartilage in the Yucatan Minipig.Cartilage · 2021Article
- Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges.Bioactive materials · 2021Review
- Recent Advances in Understanding the Role of Cartilage Lubrication in Osteoarthritis.Molecules (Basel, Switzerland) · 2021Review
- "Lessons from Rare Forms of Osteoarthritis".Calcified tissue international · 2021Review
- Nanoparticle-Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy.Nano-micro letters · 2021Review
- Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches-A Review.Polymers · 2021Review
- Synergistic Microgel-Reinforced Hydrogels as High-Performance Lubricants.ACS macro letters · 2020Article
- PEPTIDE-MODIFIED CHONDROITIN SULFATE REDUCES COEFFICIENT OF FRICTION AT ARTICULAR CARTILAGE SURFACE.Current research in biotechnology · 2020Article
- Nanostructured Coating for Biomaterial Lubrication through Biomacromolecular Recruitment.ACS applied materials & interfaces · 2020Article
- Mega macromolecules as single molecule lubricants for hard and soft surfaces.Nature communications · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
We report the design of a diblock copolymer with architecture and function inspired by the lubricating glycoprotein lubricin. This diblock copolymer, synthesized by sequential reversible addition-fragmentation chain-transfer polymerization, consists of a cationic cartilage-binding domain and a brush-lubricating domain. It reduces the coefficient of friction of articular cartilage under boundary mode conditions (0.088 ± 0.039) to a level equivalent to that provided by lubricin (0.093 ± 0.011). Additionally, both the EC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.