Evidence map›Paper›PMID 31164412›Full record

ArticleMolecular cancer research : MCR2019

T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis.

Christophe Cataisson, Rosalba Salcedo, Aleksandra M Michalowski, Mary Klosterman, Shruti Naik, Luowei Li, Michelle J Pan, Amalia Sweet, Jin-Qiu Chen, Laurie G Kostecka and 11 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 1 country.

Christophe Cataisson *Laboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Rosalba Salcedo *Cancer and Inflammation Program (CIP), NCI, Bethesda Maryland.
Aleksandra M MichalowskiLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Mary KlostermanLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Shruti NaikDepartment of Pathology and Ronald O. Perelman Department of Dermatology, NYU School of Medicine, New York, New York.
Luowei LiLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Michelle J PanLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Amalia SweetLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Jin-Qiu ChenCollaborative Protein Technology Resource, Center for Cancer Research, NCI, Bethesda, Maryland.
Laurie G KosteckaLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.ORCID 0000-0003-2124-3485
Megan KarwanLeidos Biomedical Research, Inc., Frederick, Maryland.
Loretta SmithCancer and Inflammation Program (CIP), NCI, Bethesda Maryland.
Ren-Ming DaiLeidos Biomedical Research, Inc., Frederick, Maryland.
C Andrew StewartCancer and Inflammation Program (CIP), NCI, Bethesda Maryland.ORCID 0000-0001-7936-447X
Lyudmila LyakhCancer and Inflammation Program (CIP), NCI, Bethesda Maryland.
Wang-Ting HsiehLeidos Biomedical Research, Inc., Frederick, Maryland.
Asra KhanCancer and Inflammation Program (CIP), NCI, Bethesda Maryland.
Howard YangLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Maxwell LeeLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland.
Giorgio TrinchieriCancer and Inflammation Program (CIP), NCI, Bethesda Maryland. yuspas@mail.nih.gov trinchig@mail.nih.gov.
Stuart H YuspaLaboratory of Cancer Biology and Genetics, NCI, Bethesda, Maryland. yuspas@mail.nih.gov trinchig@mail.nih.gov.
Cancer Genetics (United States) · USInflammation Research Foundation · USLeidos (United States) · USCenter for Cancer Research · USNew York University · US

Funding

Role of inflammation, innate resistance, and immunity in carcinogenesis.ZIABC010793 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2009 to 2025
$16.8M
Interacting Signaling Pathways that Initiate Squamous Cell CarcinogenesisZIABC004504 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YUSPA, STUART H. · 2009 to 2022
$15.7M
Integrated analyses of genetics, epigenetics, and gene expressionZIHBC011703 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LEE, MAXWELL · 2016 to 2025
$10.9M
IFN-Lambda Signal TransductionZ01BC010737 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GAMERO, ANA M · 2006 to 2008
$278k
Intramural NIH HHS Z01 BC010737Intramural NIH HHS ZIA BC004504Intramural NIH HHS ZIA BC010793
6 · The paper itself

Abstract

Cancer development requires a favorable tissue microenvironment. By deleting

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCarcinogenesisFemaleGene Expression Regulation, NeoplasticHumansInterleukin-17KeratinocytesMiceMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88Neoplasms, Glandular and EpithelialNF-kappa Bras ProteinsReceptors, Interleukin-1 Type IAdaptor Proteins, Signal TransducingIl17a protein, mouseIL1R1 protein, mouseInterleukin-17Myd88 protein, mouseMyeloid Differentiation Factor 88NF-kappa BNfkbiz protein, mouseras ProteinsReceptors, Interleukin-1 Type I

Identifiers

PMID31164412
PMCPMC6720116
OpenAlexW2948885010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.