Evidence map›Paper›PMID 31164411›Full record

ArticleBioscience reports2019

UGT2B17 and miR-224 contribute to hormone dependency trends in adenocarcinoma and squamous cell carcinoma of esophagus.

Xiangyao Lian, Ancha Baranova, Jimmy Ngo, Guiping Yu, Hongbao Cao

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Xiangyao LianDepartment of Oncology, The Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China.
Ancha BaranovaSchool of Systems Biology, George Mason University (GMU), Fairfax, VA 22030, U.S.A.
Jimmy NgoSchool of Systems Biology, George Mason University (GMU), Fairfax, VA 22030, U.S.A.
Guiping YuDepartment of Cardiothoracic Surgery, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin 214400, Jiangsu Province, China xiaoyuer97103@163.com g.yu2018@gousinfo.com h.cao@elsevier.com.ORCID 0000-0002-9718-8905
Hongbao CaoDepartment of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China xiaoyuer97103@163.com g.yu2018@gousinfo.com h.cao@elsevier.com.
George Mason University · USChengde Medical University · CNJiangyin People's Hospital · CNRELX Group (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA) are the two main subtypes of esophageal cancer. Genetics underpinnings of EA are substantially less understood than that of ESCC. A large-scale relation data analysis was conducted to explore the genes implicated with either EA or ESCC, or both. Each gene linked to ESCC but not EA was further explored in mega-analysis of six independently collected EA RNA expression datasets. A multiple linear regression (MLR) model was built to study the possible influence of sample size, population region, and study date on the gene expression data in EA. Finally, a functional pathway analysis was conducted to identify the possible linkage between EA and the genes identified as novel significant contributors. We have identified 276 genes associated with EA, 1088 with ESCC, with a significant (

Indexed as

AdenocarcinomaCell Line, TumorCell ProliferationEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleGene Expression Regulation, NeoplasticGlucuronosyltransferaseHumansMaleMicroRNAsMiddle AgedMinor Histocompatibility AntigensNeoplasm ProteinsNeoplasms, Hormone-DependentSignal TransductionGlucuronosyltransferaseMicroRNAsMinor Histocompatibility AntigensMIRN224 microRNA, humanNeoplasm ProteinsUGT2B17 protein, humanesophageal adenocarcinomaFunctional Pathway analysismega-analysismultiple linear regression analysissquamous cell carcinoma

Identifiers

PMID31164411
PMCPMC6609598
OpenAlexW2948243617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.