ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2019
Motoric cognitive risk syndrome and predictors of transition to dementia: A multicenter study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07225400 (Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment), which is not on this map. Cited by 53 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Motoric Cognitive Risk Syndrome and the Risk of Incident Dementia: A Systematic Review and Meta-Analysis of Cohort Studies.Gerontology · 2024Pooled it
- How gait influences frailty models and health-related outcomes in clinical-based and population-based studies: a systematic review.Journal of cachexia, sarcopenia and muscle · 2021Pooled it
- Article
- Age-friendly environments and incident motoric cognitive risk syndrome in older adults: A prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Clinical and neuroimaging correlates of motoric cognitive risk syndrome in cerebral small vessel disease: a cross-sectional study.Frontiers in aging neuroscience · 2026Article
- Proactive health management strategies for older adults with motoric cognitive risk syndrome: a scoping review.BMC geriatrics · 2025Article
- How physical activity influences motoric cognitive risk syndrome in older adults.BMC geriatrics · 2025Article
- Retinal microvascular alterations in motoric cognitive risk syndrome: an OCT angiography study.International ophthalmology · 2025Observational
- Cognitive and physical functions among Chinese community-dwelling older adults with motoric cognitive risk syndrome: A prospective cohort study.International journal of nursing sciences · 2025Article
- From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome.Aging and disease · 2025Review
- Motoric Cognitive Risk Syndrome Associated With Risk of Frailty and Likelihood of Reversion in Older Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- Development and Validation of a Predictive Model for Activities of Daily Living Dysfunction in Older Adults: Retrospective Analysis of Data From the China Health and Retirement Longitudinal Study.JMIR medical informatics · 2025Article
- Electrocardiographic markers in Motoric Cognitive Risk syndrome.Gerontology · 2025Article
- A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease.EBioMedicine · 2025Article
- Development and validation of a risk prediction model for motoric cognitive risk syndrome in older adults.Aging clinical and experimental research · 2024Article
- Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study.JMIR research protocols · 2024Observational
- Association of 8-hydroxy-2'-deoxyguanosine with motoric cognitive risk in elderly Chinese people: RUGAO longevity and aging cross-sectional study.BMC geriatrics · 2024Article
- "Cognitive" Criteria in Older Adults With Slow Gait Speed: Implications for Motoric Cognitive Risk Syndrome.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Review
- Social frailty and the incidence of motoric cognitive risk syndrome in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionTo report clinical predictors of transition to dementia in motoric cognitive risk syndrome (MCR), a predementia syndrome characterized by cognitive complaints and slow gait.
methodsWe examined if cognitive or motoric impairments predicted transition to dementia in 610 older adults with MCR from three cohorts. Association of cognitive (logical memory, clinical dementia rating, cognitive complaint severity, and Mini-Mental State Examination) and motoric factors (gait velocity) with dementia risk was computed using Cox models.
resultsThere were 156 incident dementias (134 Alzheimer's disease). In the pooled sample, logical memory (adjusted hazard ratio [aHR] 0.91), cognitive complaint severity (aHR 1.53), and Mini-Mental State Examination (aHR 0.75) predicted transition of MCR to dementia. Clinical dementia rating score ≥0.5 predicted dementia (aHR 3.18) in one cohort. Gait velocity did not predict dementia. DISCUSSION: While MCR is a motoric-based predementia syndrome, severity of cognitive but not motoric impairments predicts conversion to dementia.
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