ArticleRadiation oncology (London, England)2019
Preliminary exploration of clinical factors affecting acute toxicity and quality of life after carbon ion therapy for prostate cancer.
Article in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02739659 (Carbon Ion Radiotherapy for the Treatment of Localized Prostate Cancer), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Carbon Ion Radiotherapy for the Treatment of Localized Prostate Cancer
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Does particle radiation have superior radiobiological advantages for prostate cancer cells? A systematic review of in vitro studies.European journal of medical research · 2022Pooled it
- Clinical Efficacy and Safety of Proton and Carbon Ion Radiotherapy for Prostate Cancer: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Predictors of acute genitourinary toxicity in real-time image-gated spot-scanning proton beam therapy for prostate cancer.Journal of radiation research · 2026Article
- Carbon ion radiation therapy in prostate cancer: The importance of dosage.World journal of radiology · 2024Article
- Clinical indications and future directions of carbon-ion radiotherapy: a narrative review.Ewha medical journal · 2024Review
- Dosimetric comparison between stereotactic body radiotherapy and carbon-ion radiation therapy for prostate cancer.Quantitative imaging in medicine and surgery · 2023Article
- Acute toxicity and patient-reported symptom score after conventional versus moderately hypofractionated proton therapy for prostate cancer.Journal of medical radiation sciences · 2022Article
- Flourish of Proton and Carbon Ion Radiotherapy in China.Frontiers in oncology · 2022Review
- Dosimetric impact of using a commercial metal artifact reduction tool in carbon ion therapy in patients with hip prostheses.Journal of applied clinical medical physics · 2021Article
- PretreatmentAnnals of nuclear medicine · 2021Article
- Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy.Journal of radiation research · 2021Article
- Landscape of Carbon Ion Radiotherapy in Prostate Cancer: Clinical Application and Translational Research.Frontiers in oncology · 2021Article
- Androgen Deprivation Therapy Combined With Particle Therapy for Prostate Cancer: A Systematic Review.Frontiers in oncology · 2021Review
- Carbon Ion Radiotherapy Evokes a Metabolic Reprogramming and Individualized Response in Prostate Cancer.Frontiers in public health · 2021Article
- Carbon Ion Therapy: A Modern Review of an Emerging Technology.Frontiers in oncology · 2020Review
- Estimating the Number of Patients Eligible for Carbon Ion Radiotherapy in the United States.International journal of particle therapy · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo assess toxicity and quality-of-life (QOL) after carbon ion radiotherapy (CIRT) at the Shanghai Proton and Heavy Ion Center (SPHIC) and identify clinical factors that correlate with urinary, bowel and sexual function.
methodsSixty-four patients with localized prostate cancer admitted from July 2015 to January 2018 underwent CIRT. At baseline and 5 time-points after radiotherapy, we assessed patients' QOL using the 26-item edition of the Expanded Prostate Cancer Index-Composite (EPIC-26) Chinese version. Logistic regression was performed to identify clinical factors associated with acute genitourinary (GU) toxicity and relative QOL.
resultsBy the end of CIRT, urinary irritation/obstruction temporarily declined (- 7.92 ± 1.76, p < .001). For urinary incontinence, bowel and sexual QOL, the scores remained stable at 2-year follow-up. The occurrences of acute Grade 1 and 2 GU toxicity were 20.3 and 10.9%, respectively, and of late Grade 1 and 2 GU toxicity were 3.1 and 1.6%, respectively. No acute or late gastrointestinal (GI) toxicity occurred. Transurethral resection of the prostate (TURP) was a risk factor that predicted a decline in urinary related QOL, and age made a difference to bowel-related QOL. For sexual QOL, castration status was a remarkable risk factor. An international prostate symptom score (IPSS) ≥8 increased the risk of Grade 1-2 acute GU toxicity 5.3-fold.
conclusionPatients with prostate cancer had favorable QOL after CIRT. IPSS ≥8 was a risk factor to acute GU toxicity, and TURP predicted a decline in urinary QOL. Age was related to bowel QOL, and castration status was associated with sexual QOL.
trial registrationCarbon Ion Radiotherapy for the Treatment of Localized Prostate Cancer, NCT02739659 . Registered April 15, 2016.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.