Evidence map›Paper›PMID 31164094›Full record

ArticleBMC cancer2019

Endurance training slows breast tumor growth in mice by suppressing Treg cells recruitment to tumors.

Amit Hagar, Zemin Wang, Sachiko Koyama, Josua Aponte Serrano, Luma Melo, Stephanie Vargas, Richard Carpenter, John Foley

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06522971 (Exploration of the Molecular Mechanisms Behind the Effects of Physical Exercise on Response to Neoadjuvant Chemotherapy in Breast Cancer Patients), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06522971 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Exploration of the Molecular Mechanisms Behind the Effects of Physical Exercise on Response to Neoadjuvant Chemotherapy in Breast Cancer Patients

TypeinterventionalSponsorLatvian Biomedical Research and Study CentreRan2022 to 2027Enrolled55ConditionsBreast CancerArmsHigh-intensiy interval training
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amit HagarHistory & Philosophy of Science & Medicine Department, Indiana University, Morrison Hall 314, Bloomington, IN, 47405, USA. hagara@indiana.edu.ORCID http://orcid.org/0000-0002-7920-975X
Zemin WangEnvironmental Health Department, School of Public Health, Indiana University, Bloomington, IN, USA.
Sachiko KoyamaMedical Sciences Program, Indiana University School of Medicine, Bloomington, USA.
Josua Aponte SerranoIntelligent Systems Engineering Department, Indiana University, Bloomington, IN, USA.
Luma MeloHistory & Philosophy of Science & Medicine Department, Indiana University, Morrison Hall 314, Bloomington, IN, 47405, USA.
Stephanie VargasHistory & Philosophy of Science & Medicine Department, Indiana University, Morrison Hall 314, Bloomington, IN, 47405, USA.
Richard CarpenterMedical Sciences Program, Indiana University School of Medicine, Bloomington, USA.
John FoleyMedical Sciences Program, Indiana University School of Medicine, Bloomington, USA.

Funding

Indiana University Bloomington FRSP Seed Award
6 · The paper itself

Abstract

backgroundAerobic exercise has been shown to slow tumor progression in rodents and humans, but the mechanisms behind this effect are still unclear. Here we show that aerobic exercise in the form of chronic endurance training suppresses tumor recruitment of FoxP3

methodsAdult wild-type and athymic BALB/c female mice were endurance-trained for 8 weeks. Circulating leukocytes as well as muscle and liver mtDNA copy number were compared to aged-matched concurrent sedentary controls to establish systemic effects. 4 T1 murine mammary tumor cells were injected subcutaneously to the 4th mammary pad at the end of the training period. Tumor growth and survival rates were compared, together with antitumor immune response.

resultsExercised wild-type had 17% slower growth rate, 24% longer survival, and 2-fold tumor-CD

conclusionsCytotoxic T cells are a significant factor in endurance exercise-induced suppression of tumor growth. Endurance exercise enhances antitumor immune efficacy by increasing intratumoral CD8

Indexed as

Disease ProgressionEndurance TrainingPhysical Conditioning, AnimalAnimalsCell Line, TumorFemaleForkhead Transcription FactorsKaplan-Meier EstimateLactic AcidMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CMice, NudePilot ProjectsSurvival RateT-Lymphocytes, CytotoxicForkhead Transcription FactorsFoxp3 protein, mouseLactic AcidCD8+/FoxP3+ ratioEndurance exerciseForced running wheelsHypoxiaMurine mammary tumorSolid tumor progressionTreg cells

Identifiers

PMID31164094
PMCPMC6549262

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.