Evidence map›Paper›PMID 31164024›Full record

ReviewLeukemia & lymphoma2019

Maximizing the effectiveness of oral therapies in lymphoid cancers: research gaps and unmet needs.

Alix Y L Zackon, Amy A Ayers, Katherine A Yeager, Mary L Somma, Jonathan W Friedberg, Christopher R Flowers, Loretta J Nastoupil

Open access · greenAbstract readReview
In one paragraph

Review in Leukemia & lymphoma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Alix Y L ZackonWinship Cancer Institute, Emory University , Atlanta , GA , USA.
Amy A AyersWinship Cancer Institute, Emory University , Atlanta , GA , USA.
Katherine A YeagerWinship Cancer Institute, Emory University , Atlanta , GA , USA.
Mary L SommaScientific and Research Programs, Lymphoma Research Foundation , New York , NY , USA.
Jonathan W FriedbergWilmot Cancer Institute, University of Rochester , Rochester , NY , USA.
Christopher R FlowersWinship Cancer Institute, Emory University , Atlanta , GA , USA.
Loretta J NastoupilMD Anderson Cancer Center, The University of Texas , Houston , TX , USA.
Emory University · USLymphoma Research Foundation · USThe University of Texas MD Anderson Cancer Center · USUniversity of Rochester · US

Funding

The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study (Supplement)U01CA195568 · NCI · MAYO CLINIC ROCHESTER · PI CERHAN, JAMES R, FLOWERS, CHRISTOPHER R · 2015 to 2025
$22.1M
Mentored Patient Oriented Research in LymphomaK24CA208132 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FLOWERS, CHRISTOPHER R · 2016 to 2020
$822k
NCI NIH HHS K24 CA208132NCI NIH HHS U01 CA195568
6 · The paper itself

Abstract

Oral therapies have become a common treatment choice for several lymphoid cancers. While therapeutic efficacy and patient preference for this therapy type have been reported, there is a lack of knowledge about its effectiveness for lymphoma in clinical practice, particularly in regard to the effects of medication nonadherence. While studies of oral medications in other diseases have shown that adherence is a major factor in outcomes and costs, there is scant research investigating adherence specifically in lymphoma patients, who face unique challenges in their diseases and treatments. To address the limited data available, we constructed a conceptual model and highlighted key opportunities for future research to better elucidate oral therapy adherence in lymphoma. This research will hopefully improve understanding and efficacy of oral treatment for lymphoma patients, while also informing other cancers utilizing oral therapies currently and in the future.

Indexed as

Administration, OralAntineoplastic Combined Chemotherapy ProtocolsClinical Trials as TopicHumansLeukemia, LymphoidLymphomaMedication AdherenceTreatment OutcomeadherencelymphomaOral therapy

Identifiers

PMID31164024
PMCPMC6791753
OpenAlexW2948442338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.