ArticleThe American journal of psychiatry2019
Association of Choroid Plexus Enlargement With Cognitive, Inflammatory, and Structural Phenotypes Across the Psychosis Spectrum.
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Article in The American journal of psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.
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93citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
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Who cites it
93 citing papers in PubMed, 2 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis.Molecular psychiatry · 2022Pooled it
- The Role of Peripheral Inflammation in Clinical Outcome and Brain Imaging Abnormalities in Psychosis: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Altered Neurofluid Dynamics Markers in Middle-Aged and Older Women With Insomnia: A Multiparametric MR Neuroimaging Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Regional choroid plexus calcifications and their associations with aging, brain structure, and disease.bioRxiv : the preprint server for biology · 2026Article
- DTI-ALPS as a marker of glymphatic function: Review of the literature findings, methodology, and interpretation.Neuroimage. Reports · 2026Article
- Choroid plexus inflammation in bipolar disorder.Brain, behavior, and immunity · 2026Article
- The choroid plexus, cognitive decline, and incident dementia: insights from the UK Biobank.Molecular psychiatry · 2026Article
- Automatic choroid plexus assessment in SLE: a deep learning-enabled study.Neuroradiology · 2026Article
- Choroid plexus alterations in long COVID and their associations with IL-6.European archives of psychiatry and clinical neuroscience · 2026Article
- The influence of vascular risk factors and aging on choroid plexus enlargement.European radiology · 2026Article
- A frontotemporal free water signature associated to interleukin-8 and cognitive impairment in schizophrenia with comorbidity of metabolic syndrome.Brain, behavior, & immunity - health · 2026Article
- Linking peripheral low-grade inflammation and blood-cerebrospinal fluid barrier leakage in schizophrenia spectrum disorders - A retrospective analysis.Brain, behavior, & immunity - health · 2026Article
- Dysregulation of Hippo Signaling Pathway as a Convergent Mechanism Underlying Choroid Plexus Defects in Bipolar Disorder.bioRxiv : the preprint server for biology · 2026Article
- Associations of inflammatory biomarkers with brain atrophy and clinical scores in schizophrenia patients with autistic features.BMC research notes · 2026Article
- Choroidal Vascularity Index in Schizophrenia Compared to Healthy Subjects: A Cross-Sectional Study.Health science reports · 2026Article
- Choroid plexus enlargement contributes to CSVD progression and white matter microstructural deterioration via brain-fluid dysregulation.Alzheimer's research & therapy · 2026Article
- Morphological and Molecular Characteristics of Choroid Plexus Epithelium in Aged Brains.International journal of molecular sciences · 2026Review
- Immunohistochemical Analysis of Tom20 in Choroid Plexus Epithelial Cells From Elderly Brains With Neurodegenerative Diseases.Neuropathology : official journal of the Japanese Society of Neuropathology · 2026Article
- A probabilistic deep learning approach for choroid plexus segmentation in autism spectrum disorder.NPP - digital psychiatry and neuroscience · 2026Article
- Self images: an empirical enquiry into Rembrandt's self-portraits.Frontiers in psychiatry · 2026Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 1 institution in 2 countries.
Paulo LizanoThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Olivia LutzThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
George LingThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Adam M LeeThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Seenae EumThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Jeffrey R BishopThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Sinead KellyThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Ofer PasternakThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Brett ClementzThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Godfrey PearlsonThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
John A SweeneyThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Elliot GershonThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Carol TammingaThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
Matcheri KeshavanThe Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston (Lizano, Lutz, Ling, Kelly, Keshavan); the Department of Psychiatry, Harvard Medical School, Boston (Lizano, Kelly, Pasternak, Keshavan); the University of Minnesota Academic Health Center, Minneapolis (Lee, Eum, Bishop); the Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Clementz); the Olin Neuropsychiatry Research Center/Institute of Living, Hartford Hospital, Hartford, Conn. (Pearlson); the Department of Psychiatry, University of Cincinnati (Sweeney); the Department of Psychiatry, University of Chicago (Gershon); and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tamminga).
University of Georgia · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MUniversity of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0MBipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8MBipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6MStability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2MBipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077852 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI THAKER, GUNVANT K · 2007 to 2010
$3.5MBipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077862 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SWEENEY, JOHN A · 2007 to 2010
$3.1MNCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH077851NIMH NIH HHS R01 MH077852NIMH NIH HHS R01 MH077862NIMH NIH HHS R01 MH077945NIMH NIH HHS R01 MH078113
Abstract
objectiveThe choroid plexus is an important physiological barrier and produces CSF and neurotrophic, angiogenic, and inflammatory factors involved in brain development. Choroid plexus abnormalities have been implicated in both schizophrenia and bipolar disorder. A previous choroid plexus transcriptomic analysis of schizophrenia identified an upregulation of immune and inflammatory genes that correlated with peripheral inflammatory markers. The purpose of this study was to examine choroid plexus volume in probands across the psychosis spectrum and in their first-degree and axis II cluster A relatives, as well as choroid plexus familiality and choroid plexus covariance with clinical, cognitive, brain, and peripheral marker measures.
methodsChoroid plexus volume was quantified (using FreeSurfer) in psychosis probands, their first-degree and axis II cluster A relatives, and healthy control subjects, organized by DSM-IV-TR diagnosis. Analyte, structural connectivity, and genotype data were collected from a subset of study subjects.
resultsChoroid plexus volume was significantly larger in probands compared with first-degree relatives or healthy control subjects; first-degree relatives had intermediate enlargement compared with healthy control subjects; and total choroid plexus volume was significantly heritable. Larger volume was associated with worse cognition, smaller total gray matter and amygdala volume, larger lateral ventricle volume, and lower structural connectivity in probands. Associations between larger volume and higher levels of interleukin 6 in probands was also observed.
conclusionsThese findings suggest the involvement of the choroid plexus across the psychosis spectrum with a potential pathophysiological mechanism involving the neuroimmune axis, which functions in maintaining brain homeostasis and interacting with the peripheral immune and inflammatory system. The choroid plexus may be an important target in future research.
Indexed as
CognitionAdultCase-Control StudiesChoroid PlexusFemaleHumansInflammationMagnetic Resonance ImagingMaleNeuroimagingOrgan SizePhenotypePsychotic DisordersChoroid PlexusPsychosis
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