Evidence map›Paper›PMID 31163654›Full record

ReviewChildren (Basel, Switzerland)2019

Differential Diagnosis of Pediatric Multiple Sclerosis.

Maria Milagros Galardi, Cristina Gaudioso, Saumel Ahmadi, Emily Evans, Laura Gilbert, Soe Mar

Open access · goldAbstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  3. Review
  4. Review
  5. The State of the Art of Pediatric Multiple Sclerosis.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maria Milagros GalardiDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA. mmgalardi@wustl.edu.
Cristina GaudiosoDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA. gaudioso@wustl.edu.
Saumel AhmadiDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA. saumel@wustl.edu.
Emily EvansDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA. eevans23@wustl.edu.
Laura GilbertDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA. l.gilbert@wustl.edu.
Soe MarDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA. mars@wustl.edu.
Washington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The differential diagnosis of pediatric multiple sclerosis (MS) can be broad and pose diagnostic challenges, particularly at initial presentation. Among demyelinating entities, neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibodies (MOG-ab) associated disorders, and acute disseminated encephalomyelitis (ADEM) are now well-known as unique disease processes and yet continue to overlap with MS in regards to clinical presentation and imaging. In non-inflammatory entities, such as metabolic disorders and leukodystrophies, an erroneous diagnosis of MS can be made even while applying appropriate diagnostic criteria. Knowing the epidemiology, typical clinical presentation, diagnostic criteria, and ancillary test results in each disease, can aid in making the correct diagnosis by contrasting these features with those of pediatric MS. Determining the correct diagnosis early, allows for efficient and effective treatment as well as appropriate prognostication.

Indexed as

ADEMdemyelinationleukodystrophiesmetabolic disordersMOG-abNMOSDpediatric multiple sclerosis

Identifiers

PMID31163654
PMCPMC6617098
OpenAlexW2948877943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.